Scope of Responsibilities
- All aspects of mammalian cell culture and aseptic technique.
- Culturing different cell types including primary cells, cell lines, and iPSC cells.
- Maintaining small-scale bioreactors from 0.25mL to 10L scale in perfusion mode.
- Cell transfection, transduction, and other genetic manipulation techniques.
- Development of unit operations suitable for integration in a continuous manufacturing process.
- Maintain accurate and reliable records including database management, batch records, lab notebooks, and all other pertinent documentation.
- Writing and/or contributing to SOPs, batch records, protocols and reports.
- Cross training and collaboration with colleagues on harvest and downstream purification technologies
- Comply with all environmental health and safety standards.
- This is a hands-on lab-based position requiring a flexible schedule based on experimental work (some weekend work may be required).
Minimum Qualifications
- Ph.D. in chemical engineering, biology, biotechnology, or related discipline or Master’s degree with 5+ years or Bachelor’s degree with 8+ years of relevant experience
- Strong understanding of tissue culture and aseptic technique
- Experience working with bioreactors in perfusion mode.
- Strong team worker who is also independently motivated, detail oriented and possesses good problem-solving capabilities.
- Demonstrated ability to work both independently as well as part of interdisciplinary development team.
- Excellent organizational skills
- Strong verbal and written skills; able to handle confidential information and material appropriately
Preferred Qualifications
- Track record of success in biopharmaceutical process development
- Experience with continuous biomanufacturing process development
- Experience with scale-up and scale-down of perfusion cell culture processes
- Experience/knowledge of extracellular vesicle process development
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What We Do
Landmark Bio is a collective endeavor launched by leaders from academia, the life sciences industry, and world-renowned research hospitals to accelerate development and industrialization of next-generation genomic medicine. Inspired by recent advancements in cell and gene therapy, Landmark Bio was established to remove barriers in drug development, create accessible capability, expertise, and solutions, and offer a collaboration platform to advance manufacturing technologies for the new generation of medicines to come. Founding partners include Harvard University, Massachusetts Institute of Technology (MIT), Cytiva, FUJIFILM Diosynth Biotechnologies (FDB), and Alexandria Real Estate Equities, Inc. Other collaborating institutions include Beth Israel Deaconess Medical Center, Boston Children’s Hospital, Mass General Brigham, and the Dana-Farber Cancer Institute. For more information please contact [email protected]
Why Work With Us
Landmark Bio was conceived to accelerate life sciences innovation. Our cross-sector network, expert staff and consultants, state-of-the-art facility, and broad definition of how a true partner can expedite translational research make us unique. Our mission Is to translate groundbreaking research into life-changing therapies.
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