Responsibilites
- Play a key role in process development for Senti's cell therapy development programs, with focus on culture expanded allogeneic products, including natural killer cells (NKs) and other therapeutic cell modalities.
- Work closely with the CDMO MSAT team to understand key requirements and guide decision making to enable seamless transfers and process optimizations.
- Develop internal capability for larger scale bioreactor-based generation of genetically modified cells suitable for transfer to a GMP facility.
- Maintain thought leadership with the current cell therapy ecosystem and bring best practices to the organization.
- Create process monitoring charts, support RCAs and occasionally be a person in plant.
- Coordinate tasks across multiple projects. Make decisions on prioritization and planning. Be the key driver to meet project timelines and milestones.
- Lead in design, development, and execution of process development studies to aid in optimization and characterization of cell manufacturing processes
- Apply knowledge of immune cell biology to establish process robustness
- Review executed batch records, extract and trend data, and identify areas for improvement
- Support regulatory filings through review of technical sections
Qualifications
- BS/BA degree with 6+ years experience or MS/PhD degree with 4+ years experience in a cell therapy development setting.
- 4+ years of cell therapy process development experience from proof-of-concept to clinical manufacturing, preferably with immunology cells (NKs, T, HSCs, etc.)
- Experience with lentiviral, retroviral, and other ex vivo cell engineering vectors a plus.
- Familiarity with IND regulatory requirements, GMP environments, and quality documentation.
- Demonstrated ability to work independently in a multi-functional project at a fast moving organization.
Salary and Benefits
- The base hourly range for this role is $62-$70/hr. Starting pay is determined by multiple job-related factors including a candidate’s skills, education and experience level, benchmark, and internal parity.
- Significant growth opportunity as the company expands.
- Empathetic, supportive, and collaborative colleagues and work environments
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What We Do
Our mission is to create a new generation of smarter medicines that outmaneuver complex diseases in ways previously inconceivable. To accomplish this mission, we are building a synthetic biology platform that could enable us to program next-generation cell and gene therapies with what we refer to as “gene circuits”. These gene circuits, which are created from novel and proprietary combinations of DNA sequences, are intended to reprogram cells with biological logic to sense inputs, compute decisions and respond to their cellular environments. We are designing gene circuits to improve the “intelligence” of cell and gene therapies in order to enhance their therapeutic effectiveness against a broad range of diseases that conventional medicines do not readily address.
For more information, please visit the Senti Bio website at https://www.sentibio.com.
