Senti Bio is seeking a highly motivated and experienced individual with a background in Analytical Development. The successful candidate will contribute to the advancement of Senti’s proprietary immunotherapeutic cell engineering platforms into the clinic. The role will drive the development of flow cytometry-based methods for characterization and release of Senti’s drug products. This will entail supporting the development of new methods, the qualification and transfer of methods to QC, and characterization of manufacturing processes for CMC filings. We are looking for someone with a technically strong background with flow cytometry and CMC assay development wanting to build on their Analytical Development experience.
Responsibilities
- Collaborate with R&D to understand product characteristics
- Identify and develop key flow cytometry assays for characterization and release of drug product and manufacturing processes.
- Drive the development, qualification, and transfer of release methods to QC
- Collaborate with AD team in the development of other assays such as immune- or cell-based functional assays
- Support the writing of CMC sections of Regulatory filings
- Write Test Methods and SOPs
- Independently perform experiments, analyze data, and present results
- Successfully execute and document laboratory procedures and experiments with great attention to detail.
Qualifications
- Masters’ degree in Cell Biology or related life science field
- Industry or academic experience with CAR-T, CAR-NK, cell therapy, or immunology is a plus.
- 4-6 years of hands-on industry experience in Analytical Development, Quality, or a related field
- Significant experience with CGMP workflows, from development to pre-qualification, qualification, validation, and tech transfer to QC
- Significant experience with developing complex flow cytometry-based assays
- Experience with Regulatory filings
- Ability to multitask and meet deadlines in a fast-paced environment
- Ability to think critically and demonstrate troubleshooting and problem-solving skills
- Must be a team player, proactive and willing to work in a small team environment
- Must have excellent verbal and written communication skills, including experience delivering presentations to executive stakeholders and external partners
- Proficient with MS office and other commonly used software and technology platforms
- Self-motivated and eager to take on temporary responsibilities outside of initial job description
Salary and Benefits
- Base pay and stock options to be determined based on application qualifications with the aim of being competitive with similar roles in the area
- Significant growth opportunity as the company expands
- Empathetic, supportive and collaborative colleagues and work environment
Top Skills
What We Do
Our mission is to create a new generation of smarter medicines that outmaneuver complex diseases in ways previously inconceivable. To accomplish this mission, we are building a synthetic biology platform that could enable us to program next-generation cell and gene therapies with what we refer to as “gene circuits”. These gene circuits, which are created from novel and proprietary combinations of DNA sequences, are intended to reprogram cells with biological logic to sense inputs, compute decisions and respond to their cellular environments. We are designing gene circuits to improve the “intelligence” of cell and gene therapies in order to enhance their therapeutic effectiveness against a broad range of diseases that conventional medicines do not readily address.
For more information, please visit the Senti Bio website at https://www.sentibio.com.
