Vir Biotechnology, Inc. is an immunology company focused on powering the immune system to transform lives by treating and preventing infectious diseases and other serious conditions, including viral-associated diseases. Vir has assembled two technology platforms that are designed to modulate the immune system by exploiting critical observations of natural immune processes. Its current clinical development pipeline consists of product candidates targeting hepatitis delta and hepatitis B viruses and human immunodeficiency virus. Vir has several preclinical candidates in its pipeline, including those targeting influenza A and B, COVID-19, RSV/MPV and HPV.
We believe the success of our colleagues drives the success of our mission. We are committed to creating a company passionate about equality, inclusion, and respect. When everyone feels supported and encouraged to give their best, we will collectively deliver outstanding results. We are proud to be the first company to be ranked at the top of the Deloitte Fast 500 list two years in a row (2023 & 2022)!
Vir Biotechnology is looking for a Scientist II, Upstream Process Development to develop antibody cell culture processes used for cGMP production of Vir's pipeline of therapeutic antibodies. Reporting to the Director, Process Development you will work primarily in the laboratory to design, execute and evaluate cell culture process development experiments at pilot scale for early and/or late-stage clinical development programs. You will analyze and optimize complex experiments in a team setting and work toward scalable cell culture processes to produce recombinant antibodies. You will represent your work at functional area meetings and provide support for purification development, analytical development, formulation and drug product teams, process analytics, manufacturing sciences, and other CMC functions.
This role calls for your presence in the office 4 to 5 days per week and we provide flexibility to balance work and personal life.
- Lead and implement experiments in the design, development, optimization and scale-up of protein production processes in suspension cell culture systems (shake flasks, AMBR250, bench scale bioreactors, pilot scale)
- Develop scalable mammalian cell culture and harvest processes for upstream cell culture development in collaboration with our CDMO partners
- Lead pilot scale planning, media formulations, execution of seed train, production and harvest processes
- Design scientifically rigorous experiments, using statistical DoE where applicable, execute experiments and analyze and interpret data to inform next studies
- Design and implement early-stage process development and late-stage upstream process characterization and process validation studies
- Provide technical oversight for outsourced process development and cGMP production with CDMOs
- Participate in process tech transfers and coordination of manufacturing internal and external interfaces for reporting and solving of cell culture processes
- Review process descriptions and batch records during cGMP operations and tech transfer
- Author technical process development reports, process descriptions, and other relevant process documentation including SOPs and protocols
- Perform on-site lab work including coverage of weekend work to support experiments (an estimated 8 – 16 hours/month)
- Degree in chemical engineering, biochemistry or related field
- 8 + years (with Bachelors' degree.), 6+ years (with Masters' degree) or 3 + years (with Ph.D.) of experience in protein upstream process development
- Experience operating in early stage clinical to commercial environments
- Understanding of cGMP antibody process development and production using CHO host cell expression systems
- Experience with mammalian cell culture, aseptic techniques, understanding of biochemical engineering concepts, and biochemical pathways
- Experience developing and improving scalable fed-batch, transfection, and perfusion upstream processes in PD setting
- Familiar with Bioreactor Scale-up concepts with a track record for scaling-up processes to disposable/stainless bioreactors
- Use Design of Experiments in JMP, Design Expert, or other software for statistical experimental design and data analysis
- Able to travel as needed (up to 15%)
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The expected salary range for this position is $128,500.00 to $169,500.00. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors.
Vir's compensation and benefits are aligned with the current market and commensurate with your experience and qualifications. All full-time employees receive a package that includes: compensation, bonus and equity and many other Vir benefits and perks such as: health, dental, vision, life and disability insurance benefits, non-accrual paid time off, company shut down for holidays, commuter benefits, child care reimbursement, education reimbursement, 401K match and lunch for all onsite employees!
Vir Biotechnology (“Vir”) is an equal opportunity employer. All employment decisions at Vir are based on legitimate, non-discriminatory business requirements, job duties and individual qualifications. Employment decisions are made without regard to race, color, religion, sex (including pregnancy), gender, gender identity, gender expression, sexual orientation, age, parental status, marital status, national origin, ancestry, disability, medical condition, genetic information (including family medical history), political affiliation, military service or any other legally protected characteristic.
This commitment extends to all management practices and decisions, including recruitment and hiring, compensation, appraisal systems, promotions, training and career development programs. Vir also strongly commits to providing employees with a work environment free of unlawful discrimination or harassment.
Vir Human Resources leads recruitment and employment for Vir. Unsolicited resumes sent to Vir from recruiters do not constitute any type of relationship between the recruiter and Vir and do not obligate Vir to pay fees should we hire from those resumes. We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring manager or employees.
For hires based in the United States, Vir Biotechnology, Inc., participates in E-Verify.
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What We Do
Vir Biotechnology, Inc. (in Europe, Humabs BioMed, https://bit.ly/46lQGN2) is an immunology company focused on powering the immune system to address unmet patient needs in infectious disease and beyond. Our powerful R&D engine combines our proprietary monoclonal antibody (mAb) platform with machine learning and artificial intelligence-enhanced capabilities, enabling us to engineer our rich database of human antibodies and deliver transformative medicines for diseases with significant global burden.
Our current pipeline consists of multiple clinical candidates targeting hepatitis B and hepatitis delta viruses and human immunodeficiency virus, including a potential functional cure for chronic hepatitis B and treatment for chronic hepatitis delta. Our portfolio of broad, potent investigational monoclonal antibodies also targets influenza A and B viruses, COVID-19, respiratory syncytial virus/human metapneumovirus and human papillomavirus, and our investigational T cell vaccine aims to prevent HIV. Explore our full pipeline: https://bit.ly/3tr7FPm
We collaborate with some of the world’s leaders in industry as well as government agencies and non-profit organizations enabling us to rapidly advance cutting-edge scientific discoveries and innovative technologies with the potential to benefit people around the world.
We are proud to have been ranked the fastest-growing company in North America on the 2022 Deloitte Technology Fast 500™.
Join us as we pursue our mission to transform lives.
It has come to our attention that there have been various recruitment scams targeting job seekers on LinkedIn. Vir Biotechnology, Inc. is committed to your privacy and will never request sensitive personal information including banking details through email, text message, social media or video software platforms. We also will never request a financial commitment from a candidate as part of the application process. Learn more about Vir’s recruiting process: https://bit.ly/461EgJN