Verve is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines. The company’s initial three programs – VERVE-101, VERVE-102, and VERVE-201 – target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. VERVE-101 and VERVE-102 are designed to permanently turn off the PCSK9 gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE-201 is designed to permanently turn off the ANGPTL3 gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia. In 2023, Verve was named a Top Place to Work by The Boston Globe for the third consecutive year. Verve is headquartered in Boston, Massachusetts.
The Position
Verve is seeking a Scientist II with experience in developing CRISPR-Cas9 based gene editing technologies, with a particular emphasis on analyzing gene editing outcomes. This individual will help advance our early research efforts to preclinical and clinical development using cellular and animal models. They will have the opportunity to translate basic research findings into novel therapeutic strategies that may eventually support clinical drug development.
We are considering local candidates at this time.
Job Responsibilities
- Design and execute molecular and cell-based assays to advance our development programs. Including use of enzymatic/PCR based methods (RT-PCR, qRT-PCR, standard, etc) to assess gene editing outcomes using next generation sequencing.
- Write protocols, perform experiments, organize data, analyze data, interpret results, and record experiments in an electronic lab notebook, and summarize work in presentations and technical reports.
- Independently lead and run laboratory experiments to support and advance discovery efforts.
- Conduct research across the gene editing field to develop techniques in-house.
- Propose and implement new techniques for on- and off-target gene editing analysis.
- Collaborate with multiple cross-functional teams, including analytical development, Editor development, NGS, and bioinformatics.
- Training and mentoring of more junior team members.
- Other duties as assigned.
Qualifications
- Ph.D. in Biochemistry, Molecular biology, Cell biology or related fields with at least 2 years of relevant industry experience or;
- M.S. in Biochemistry, Molecular biology, Cell biology or related fields with at least 7 years of relevant industry experience or;
- B.S. in Biochemistry, Molecular biology, Cell biology or related fields with at least 9 years of relevant industry experience.
- Experience with gene editing and/or advanced molecular biology strongly preferred.
- Advanced experience in mammalian cell culture required.
- Strong molecular biology experience, proficiency in PCR, RT-PCR, qPCR, ddPCR and protein quantification.
- Knowledge of current gene-editing approaches used in a therapeutic context.
- Experience with next-generation sequencing library prep is desirable.
- Strong analytical and problem-solving abilities, excellent communication, and interpersonal skills.
- Collaborative and detail-oriented approach to efficient performance across multiple teams and projects in a highly matrixed environment.
Don’t check off every box in the requirements listed above? Please consider applying anyway. We want the best candidates for the job, and those candidates don’t always meet 100% of the qualifications listed. At Verve, we are dedicated to building diverse and inclusive teams who embody the values we share: grit, spirit, drive, and passion. We look forward to learning more about your unique background.
EEO Statement
Verve Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.
Recruitment & Staffing Agencies
Verve Therapeutics does not accept agency resumes unless contacted directly by internal Verve Talent Acquisition. Please do not forward resumes to Verve employees or any other company location; Verve Therapeutics is not responsible for any fees related to unsolicited resumes.
Top Skills
What We Do
Verve Therapeutics is a clinical-stage biotechnology company created with a singular focus: to protect the world from heart disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene editing, the company aims to develop transformative, once-and-done therapies for coronary heart disease. Verve’s gene editing medicines are designed to safely edit the genome of adults and mimic naturally occurring gene variants to permanently lower LDL cholesterol and triglyceride levels. The company is advancing a pipeline of precision genetic medicines, led by VERVE-101, which is being developed initially for heterozygous familial hypercholesterolemia, a potentially fatal genetic heart disease. In 2023, Verve was recognized as a "Best Places to Work" by the Boston Globe. Verve is headquartered in Boston, Massachusetts
