Scientist I

KBI Biopharma is seeking a highly skilled and motivated Analytical Scientist to join our Analytical and Formulation Sciences (AFS) team in Louisville, CO. This role is ideal for a scientist with deep expertise in protein analytics, ideally with a background in mass spectrometry and protein structural characterization. You will serve as a subject matter expert (SME), driving innovation and excellence in analytical testing to support client programs from early development through late-phase  and commercialization for biotherapeutics.
Position Responsibilities:
 

• Demonstrates expertise in the execution and interpretation of experiments that contribute to project goals.
• Expertise in mass spectrometry techniques including intact mass and subunit analysis, reduced and non-reduced peptide mapping, and PTM and sequence variant analysis.
• Significant experience is desired in optimizing multiple chromatographic modalities relevant to mass spectrometry, including SEC, RP, HILIC, and CEX.
• Familiarity with Agilent, Waters, and Thermo LC-MS systems.
• Occasional recourse to non LC-MS methods including capillary electrophoresis (SDS-CGE and icIEF), UV/Fluorescence, compendial methods, and biophysical characterization techniques on proteins (CD, FTIR, DLS, SEC-MALS, calorimetry).
• Design and strategically execute analytical experiments in support of biotherapeutics development, particularly qualification/validation and stability studies.
• Generate high-quality documentation suitable for publication and regulatory review, including technical documents and analytical test methods.
• Act as SME on client programs, providing technical guidance and representing KBI in client interactions.
• Collaborate cross-functionally with rapid analytics, process development, bioassay, and program management teams.
• Mentor and train junior scientists and associates.
• Perform peer review of data and reports related to method development, qualification, and validation, as well as characterization and stability study reports.
• Manage timelines and resources to meet project milestones and proactively advise leadership on program status and technical challenges.

Minimum Requirements:

• Ph.D. in Biochemistry, Analytical Chemistry, or a related field with 0-3 years experience; M.S. with 3-7 years experience; B.S. degree with >7 years experience.
• Adaptability to changing priorities and business needs.
• Adherence to statutory and company safety requirements.
• Strong understanding of protein structure and stability and degradation pathways leading to PTMs.
• Excellent communication skills and ability to present complex data to diverse audiences.
• Proficiency in scientific software and data analysis tools (e.g. Excel, Prism).
• Ability to work independently and collaboratively in a fast-paced environment.

Salary: $84,000-$115,000

KBI Biopharma, Inc. is an EEO/AA employer and actively seeks to diversify its work force. Therefore, all qualified applicants, regardless of race, color, national origin, religion, gender, gender identity, sexual orientation, age, disability or veteran status, are strongly encouraged to apply.

I understand that neither the completion of this application nor any other part of my consideration for employment establishes any obligation for KBI Biopharma, Inc. to hire me. If I am hired, I understand that either KBI Biopharma, Inc. or I can terminate my employment at any time and for any reason, with or without cause and without prior notice. I understand that no representative of KBI Biopharma, Inc. has the authority to make any assurance to the contrary.

I attest with my signature below that I have given to KBI Biopharma, Inc. true and complete information on this application. No requested information has been concealed. I authorize KBI Biopharma, Inc. to contact references provided for employment reference checks. If any information I have provided is untrue, or if I have concealed material information, I understand that this will constitute cause for the denial of employment or immediate dismissal.

KBI Biopharma, Inc. is an EEO/AA employer and actively seeks to diversify its work force. Therefore, all qualified applicants, regardless of race, color, national origin, religion, gender, gender identity, sexual orientation, age, disability or veteran status, are strongly encouraged to apply.

I understand that neither the completion of this application nor any other part of my consideration for employment establishes any obligation for KBI Biopharma, Inc. to hire me. If I am hired, I understand that either KBI Biopharma, Inc. or I can terminate my employment at any time and for any reason, with or without cause and without prior notice. I understand that no representative of KBI Biopharma, Inc. has the authority to make any assurance to the contrary.

I attest with my signature below that I have given to KBI Biopharma, Inc. true and complete information on this application. No requested information has been concealed. I authorize KBI Biopharma, Inc. to contact references provided for employment reference checks. If any information I have provided is untrue, or if I have concealed material information, I understand that this will constitute cause for the denial of employment or immediate dismissal.