The Position:
The Drug Metabolism and Pharmacokinetics (DMPK) team at Maze Therapeutics is seeking a qualified and highly motivated Scientist I to join us in advancing our therapeutic programs. In this lab-based role, you’ll apply your expertise in LC-MS/MS (QQQ) and/or LC-HRMS (Orbitrap) to measure concentrations of small molecules, analyze PK data, and generate reports that support our drug discovery efforts. You will work closely with the lead Scientist in the PK group and collaborate across multiple projects to ensure high-quality, timely data delivery. This role is ideal for someone who values precision, embraces challenges, and excels in a hands-on laboratory environment.
Your Impact:
- Prepare and process samples (plasma, blood, and tissues) for PK and/or biomarker analyses.
- Collaborate with colleagues to coordinate acquisition of test articles, study schedules, and sample management.
- Measure analyte concentrations using LC-MS, including developing and troubleshooting methods.
- Process bioanalytical data to calculate PK parameters and generate detailed PK reports.
- Partner with scientists to upload PK data into our electronic database.
- Review and QC PK data and reports from CROs or internal teams.
- Support regulatory submissions.
- Maintain thorough, organized records in electronic laboratory notebook.
Skills and Qualifications:
- A degree in chemistry or biological sciences (bachelor’s with 6+ years, master’s with 3+ years, and PhD with industry experience)
- Hands-on experience maintaining and troubleshooting analytical equipment.
- Proficiency in processing and analyzing LC-MS data independently
- Strong skills in Excel, GraphPad Prism, and scientific writing.
- A detail-oriented approach with excellent laboratory practices and the ability to write and review PK reports
- A team-oriented mindset and strong communication skills
- Additional desired, but not required skills:
- Proficiency with Certara Phoenix WinNonLin
- Experience working in regulated laboratory environments
- Familiarity with Mosaic.
About Maze Therapeutics
Maze Therapeutics is a biopharmaceutical company that is harnessing the power of human genetics to transform the lives of patients, with a focus on genetically informed therapies for common diseases, such as chronic kidney disease, and seeks to focus expertise and resources towards underserved communities. Maze applies variant functionalization in tandem with advanced data science methods and a robust suite of research and development capabilities to advance a pipeline of novel precision medicines. Maze has developed the Maze Compass Platform™, a proprietary, purpose-built platform to understand and integrate the critical step of variant functionalization into each stage of drug development. Utilizing the Maze Compass Platform™, Maze is building a broad portfolio of wholly owned and partnered programs. Its two lead programs are focused in Chronic Kidney Disease (CKD), a condition that impacts an estimated 37m individuals. The first program in CKD addresses a genetic subset of the common disease that has a disproportionate impact on the Black Community. Maze is based in South San Francisco.
Our People
Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.
Our Core Values
Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.
Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.
Stand True – Our integrity is foundational; it guides us no matter the obstacle.
The expected annual salary range for employees located in the San Francisco Bay Area is $131,000 - $160,000. Additionally, this position is eligible for an annual performance bonus.
Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.
Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.
Top Skills
What We Do
Maze Therapeutics is translating novel genetic insights into lifesaving medicines, through an approach that integrates human genetics and functional genomics. Advances in these areas have enabled us to decode the mysteries of genetic modifiers in a range of severe diseases, which we aim to turn into medicines that mimic protective mutations. We have assembled a world-class team that we need to realize this vision, including creative scientific pioneers in genetics, experienced company builders, and biotech industry leaders.
