Scientist I, Analytical Development Bioassays

Posted Yesterday
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San Francisco, CA, USA
Hybrid
117K-147K Annually
Senior level
Biotech
The Role
Develops, optimizes, transfers, and qualifies cell-based and binding bioassays for antibody and biologic therapeutics. Performs characterization testing, prepares standards and critical reagents, troubleshoots assay issues, analyzes data, and supports process, formulation, comparability, and structure-function studies. Authors protocols, reports, and test methods for regulatory filings while serving as a bioassay subject matter expert across Tech Ops and CMC.
Summary Generated by Built In

Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN® dual-masked T-cell engagers across validated targets in solid tumor indications. Vir Biotechnology also has a preclinical portfolio of programs across a range of infectious diseases and oncologic malignancies. 

Vir Biotechnology has exclusive rights to the universal PRO-XTEN® masking platform for oncology and infectious disease. PRO-XTEN® is a trademark of Amunix Pharmaceuticals, Inc., a Sanofi company.

We believe the success of our colleagues drives the success of our mission. We are committed to creating a company where everyone feels supported and encouraged to give their best.

THE OPPORTUNITY

Vir Biotechnology is looking for a Scientist, Analytical Development. You will report to the Director, Analytical Development Bioassays and support the development of bioassays to interrogate the mechanism of action for antibody and other biologic therapeutics, including the TCE platform. You will execute cell-based activity and binding assays for characterization testing in support of Critical reagent characterization, process and formulation development, comparability and structure-activity relationship studies. You will design and conduct laboratory experiments, author protocols/reports.

This role is located in our San Francisco headquarters with an expectation of at least 5 days per week in office.

WHAT YOU'LL DO
  • Develop, optimize and qualify cell-based and binding bioassays
  • Bring in new assay modalities and technology to the group as needed
  • Prepare assay standards, controls, critical reagents, and ensure appropriate system suitability criteria are met
  • Perform characterization testing including binding ELISAs, activity / cytotoxicity and effector function assays to support structure-function studies, force degradation studies and BLA-enabling Process and Formulation development studies
  • Troubleshoot method-related issues internally and at external labs
  • Author study protocols, development/qualification reports and test methods, summarize and verify data for regulatory filings
  • Subject matter expert for Bioassays within the Tech Ops department and the broader CMC organization
WHO YOU ARE AND WHAT YOU BRING
  • Bachelor's degree with 8+ years' of industry experience, Master's degree with 6+ years' of industry experience, PhD with no industry experience
  • Experience in bioassay method development, transfer and qualification
  • Experience in data analysis of bioassays including parallel line analysis and other statistical data analysis for evaluating method performance
  • Ability to execute laboratory experiments both independently and with other team members
  • Effective at trouble-shooting method-related issues
  • Experience working on multiple projects, adjusting quickly to changes in priorities
#LI-MB1
#LI-Onsite
WHO WE ARE AND WHAT WE OFFER

The expected salary range for this position is $116,500 to $146,500 per year. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors.

Vir Biotechnology's compensation and benefits are aligned with the current market and commensurate with the person’s experience and qualifications. All full-time employees receive a package that includes compensation, bonus and equity as well as many other Vir Biotechnology benefits and perks such as health and welfare benefit plans, non-accrual paid time off, company shut down for holidays, commuter benefits, 401K match and lunch each day in the office.

Applicants must currently be authorized to work for any employer in the U.S.  We are unable to sponsor or take over sponsorship of an employment Visa at this time.

All employment decisions at Vir Biotechnology are based on legitimate, non-discriminatory business requirements, job duties and individual qualifications. Employment decisions are made without regard to any legally protected characteristics. 

This commitment extends to all management practices and decisions, including recruitment and hiring, compensation, appraisal systems, promotions, training and career development programs.  Vir Biotechnology also strongly commits to providing employees with a work environment free of unlawful conduct or harassment.

Vir Biotechnology Human Resources leads recruitment and employment for Vir Biotechnology. Unsolicited resumes sent to the company from recruiters do not constitute any type of relationship between the recruiter and Vir Biotechnology and do not obligate us to pay fees should we hire from those resumes. We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring manager or employees.

For hires based in the United States, Vir Biotechnology, participates in E-Verify.

Candidate Privacy Notice

 

Skills Required

  • Bachelor’s degree with 8 or more years of industry experience
  • Master’s degree with 6 or more years of industry experience
  • PhD with no industry experience required
  • Experience in bioassay method development, transfer, and qualification
  • Experience analyzing bioassay data, including parallel line analysis and other statistical methods
  • Ability to independently execute laboratory experiments and collaborate with team members
  • Ability to troubleshoot method-related issues
  • Experience managing multiple projects and adapting to changing priorities
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The Company
HQ: San Francisco, CA
611 Employees
Year Founded: 2016

What We Do

Vir Biotechnology, Inc. (in Europe, Humabs BioMed, https://bit.ly/46lQGN2) is an immunology company focused on powering the immune system to address unmet patient needs in infectious disease and beyond. Our powerful R&D engine combines our proprietary monoclonal antibody (mAb) platform with machine learning and artificial intelligence-enhanced capabilities, enabling us to engineer our rich database of human antibodies and deliver transformative medicines for diseases with significant global burden. Our current pipeline consists of multiple clinical candidates targeting hepatitis B and hepatitis delta viruses and human immunodeficiency virus, including a potential functional cure for chronic hepatitis B and treatment for chronic hepatitis delta. Our portfolio of broad, potent investigational monoclonal antibodies also targets influenza A and B viruses, COVID-19, respiratory syncytial virus/human metapneumovirus and human papillomavirus, and our investigational T cell vaccine aims to prevent HIV. Explore our full pipeline: https://bit.ly/3tr7FPm We collaborate with some of the world’s leaders in industry as well as government agencies and non-profit organizations enabling us to rapidly advance cutting-edge scientific discoveries and innovative technologies with the potential to benefit people around the world. We are proud to have been ranked the fastest-growing company in North America on the 2022 Deloitte Technology Fast 500™. Join us as we pursue our mission to transform lives. It has come to our attention that there have been various recruitment scams targeting job seekers on LinkedIn. Vir Biotechnology, Inc. is committed to your privacy and will never request sensitive personal information including banking details through email, text message, social media or video software platforms. We also will never request a financial commitment from a candidate as part of the application process. Learn more about Vir’s recruiting process: https://bit.ly/461EgJN

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