Cellares is seeking an innovative and highly motivated Research Associate to join the Process Development team. This individual will interface across many parts of the company and contribute significantly to the development of our advanced cell therapy manufacturing platform.
The primary focus of this position is to support the design and execution of experiments, as well as development of standard processes using the Cellares platform. The ideal candidate will be multidisciplinary and have hands-on experience in process development.
Candidates should also enjoy working in a fast-paced, mission-driven environment, and be prepared to tackle a broad selection of challenges as the company grows.
Responsibilities
Under supervision of scientists, the candidate is expected to provide hands-on support to small-scale and scale-up experiments and overall development of the Cellares advanced cell therapy manufacturing platform
Support cell line maintenance and leukopak processing, including isolation, activation, gene modification, expansion and cryopreservation
Contribute to high-quality technical documents, procedures, reports
Contribute to analysis and presentation of technical results at departmental meetings
Support technology characterization experiments informing internal equipment and consumables performance evaluation
Perform routine laboratory activities including ordering and equipment qualification/maintenance
Requirements
BS/MS or equivalent in Bioengineering, Chemical Engineering, Biology, Biochemistry, or related field
0-4 years of process development or cGMP manufacturing experience in the cell therapy or bioprocessing field
Hands-on experience in aseptic technique; experience in primary immune cell culture or bioreactors preferred
Hands-on experience with semi-automated instruments for cell therapy manufacturing
Strong problem-solving skills and attention to detail
Strong technical writing skills and experience authoring SOPs and reports
Creative, self-motivated, eager to take on a wide variety of tasks and grow with evolving technology
Self-awareness, integrity, authenticity, and a growth mindset
Skills Required
- BS/MS in Bioengineering, Chemical Engineering, Biology, Biochemistry, or related field
- 0-4 years of process development or cGMP manufacturing experience in cell therapy or bioprocessing
- Hands-on experience in aseptic technique
- Experience in primary immune cell culture
- Hands-on experience with bioreactors
- Hands-on experience with semi-automated instruments for cell therapy manufacturing
- Strong problem-solving skills and attention to detail
- Strong technical writing skills and experience authoring SOPs and reports
- Experience with leukopak processing, isolation, activation, gene modification, expansion, and cryopreservation
- Creative, self-motivated, eager to take on varied tasks and grow with evolving technology
- Self-awareness, integrity, authenticity, and a growth mindset
What We Do
Cellares is revolutionizing cell therapy manufacturing. We are developing a one-of-a-kind solution, The Cell Shuttle, to overcome the challenges associated with manufacturing so these life-saving therapies are affordable and widely available to patients who can benefit. The clinical impact of cell therapy in treating cancer has been proven, but this therapeutic approach has several limitations, especially in manufacturing, leaving extremely sick patients waiting for treatment and desperate for hope. Since cell therapy is currently produced for a single patient at a time, it is expensive to manufacture, requiring significant time and resources, and is difficult to scale. Preclinical and clinical scientists, as well as commercial cell therapy manufacturers also lack the options to fully automate their manufacturing process quickly, safely, cost-effectively and at the scale they need. The Cell Shuttle is an automated and closed end-to-end manufacturing solution that is flexible and scalable, enabling customers to run exact processes specified for their cell therapy. Compared with the current manual manufacturing processes for cell therapy, the Cell Shuttle’s next-generation automated manufacturing solution has 10 times the scalability (meaning 10 times more patient doses can be produced simultaneously), enables a three-fold reduction in process failure rates and will reduce the per-patient manufacturing cost by up to 70 percent for most processes.
