At Pliant, we believe differentiated science can make a meaningful impact. We see our success as a direct result of the central role that each team member plays in advancing our mission to develop therapies that target the disease at its source. We are seeking creative, curious and collaborative individuals who dare to succeed, are committed to making an important impact on patient’s lives and will help us build one Pliant!
We have an immediate opening for a contract Research Associate within our Translational Sciences group. This is a full-time (40 hours per week) contract position with a duration of 6 months.
This individual will join a team focused on discovery and advancement of tissue-specific delivery of drug payloads utilizing integrin receptor-binding molecules. The primary responsibility of this position will include processing samples, developing, troubleshooting and optimizing assays.
Responsibilities- Process cell and tissue-based samples through multiple molecular assays following appropriate laboratory/technical procedures with special attention to data quality and reproducibility
- Learn new laboratory techniques, troubleshoot experiments, and ensure experiments are well-designed and performed to a high standard
- Make detailed observations, analyze data promptly, and maintain accurate records
- Evaluate and clearly report experimental results to research team on a routine basis
- Contribute to development and adoption of new technologies
- Provide support for various research team projects and lab needs based using dynamic prioritization
- Actively participate in project meetings
To perform this job successfully, an individual must be able to perform each essential duty. The requirements listed below are representative of the knowledge, skill, abilities, and prior experience required.
- BA/BS degree in Molecular Biology, Immunology, Cell Biology or related field with a minimum of 3+ years full time laboratory experience in an industry or academic setting
- Experience with primary immune cell isolation from tissues and PBMCs, immune cell profiling with flow cytometry and analysis, transfection, ELISA, and immunofluorescence-based staining
- Solid experience working with Operetta high content imaging and/or Sony Sorter SH800S is aa plus
- Experience working with a variety of primary human and immune cells is preferred
- Comfortable working with ex vivo tissues e.g. human, NHP, and rodent tissues
- Ability to evaluate and clearly communicate results both verbally and in written form
- Candidate should be flexible with rapid changes in schedule based on scope/prioritization of projects
- Candidate should exhibit strong, positive attitude for teamwork and learning
- Ability to thrive in a culture of respect, accountability, transparency, and collaboration
The hourly rate for this role is $44/hr – $50/hr. Individual pay may vary based on additional factors, including, and without limitation job-related skills, experience, work location and relevant education or training.
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Skills Required
- BA/BS degree in Molecular Biology, Immunology, Cell Biology or related field with a minimum of 3+ years full time laboratory experience
- Experience with primary immune cell isolation from tissues and PBMCs
- Immune cell profiling with flow cytometry and analysis
- Transfection experience
- ELISA experience
- Immunofluorescence-based staining experience
- Comfortable working with ex vivo tissues (human, NHP, rodent)
- Ability to evaluate and clearly communicate results verbally and in writing
- Flexibility with rapid schedule changes and dynamic prioritization
- Strong positive attitude for teamwork and learning; thrive in collaborative culture
- Solid experience with Operetta high-content imaging and/or Sony Sorter SH800S
- Experience working with a variety of primary human and immune cells
What We Do
Pliant Therapeutics is a late-stage biopharmaceutical company and leader in the discovery and development of novel therapeutics for the treatment of fibrotic diseases. At Pliant, we share a commitment and a clear passion to drive innovative science towards addressing areas of unmet medical need. Together we believe we have the power to make a difference in the lives of patients and those impacted by fibrotic diseases. We believe that by harnessing the therapeutic potential of integrin biology and TGF-β modulation, there is a potential to create drug candidates aimed at halting or even reversing fibrotic diseases. Pliant recognizes the importance of diversity, equity and inclusion initiatives and that they require an evolving and ongoing commitment. Pliant is an equal opportunity employer and does not discriminate against any individual or potential candidate based on race, color, religion, sex, national origin, sexual preference or any other legally protected category. Pliant is located in South San Francisco, California, the birthplace of biotechnology. Proud to be a San Francisco Business Times Best Place to Work in 2023. Learn more about how we are breaking ground in the treatment of fibrotic diseases at www.PliantRx.com.
