Lab/Area:Finkbeiner LabDescription:
Who we are:
The Gladstone Institutes is a distinguished independent, not-for-profit research institution dedicated to advancing human health through cutting-edge medical research and education. Our work spans neuroscience, cardiovascular biology, immunology, and stem cell biology, with a focus on overcoming disease. With a team of approximately 600 members, including renowned leaders in science and biomedicine, Gladstone operates across five institutes, alongside various centers and programs. Located at the Mission Bay Campus in an award-winning building, Gladstone offers competitive salaries and benefits, providing an optimal environment for individuals to realize their full potential and make a meaningful impact on global health.
About the role:
We are seeking a highly motivated candidate for a Research Associate or Senior Research Associate to work in a dynamic, collaborative environment using cutting edge methods and technology to unravel neurodegenerative diseases. This role is very diverse, multidisciplinary and dynamic.
At the heart of our lab is a novel robotic microscopy (RM) system that can track numerous molecular features of cells over time (an example of how RM is used is found here). RM allows us to extract various types of biological information about how cells grow, mature and behave in response to candidate drugs or genetic perturbations. We then use ML approaches to extract features from our iPSC models to help identify and distinguish disease phenotypes. We have collaborations with many industries and academic groups, publish our work in high profile scientific journals, and present our work at international conferences.
What you will do:
- Help drive the scientific goals and objectives of several projects to using high throughput, human models of neurological disorders such as Amyotrophic Lateral Sclerosis (ALS) Parkinson’s Disease (PD).
- This person will have experience using CRIPSRi, induced pluripotent stem cells (iPSCs) and ideally experience with live cell imaging.
- Using a wide variety of tools, you will help orchestrate and execute a platform to model the process of neurodegeneration.
- You will work closely with our software engineers using machine learning (ML) or other approaches to phenotype disease signatures from patient cells.
What you will need:
- MS in a field of Biological Sciences or Engineering (required)
- PhD in a field of Biological Sciences or Engineering (preferred)
- Critical thinking and ability to design and execute experiments independently
- Highly organized and strong data analysis expertise
- Excellent communication and interpersonal skills
- Team player
- Must have molecular and cell biology expertise
- Self-driven and passionate about science
- At least 3 years research experience in research biology
- Widefield and/or confocal microscopy experience
- Must have previous cell culture experience at a minimum of 2 years
- The desire to learn and work on a fast-paced project.
- Experience with managing others, designing and overseeing experiments from start to finish, growing and differentiating iPSCs, and some experience using R or python.
What we prefer:
- Experience in R or Python
- iPSC culturing and differentiation into specific cell types
- Experience with live cell imaging
Hiring Range:
RA I - $27 - $31hr.
RA II - $68-$80K
RA III - $75K - $88K
Gladstone Perks & Benefits
People–work with talented, committed, and supportive teammates within an organization that values each member of its community.
A meaningful place to grow and learn–whether it’s your professional skills or scientific knowledge, we have the resources and environment to advance either so you can better support Gladstone’s mission to drive a new era of discovery in disease-oriented science and to mentor tomorrow’s leaders in an inspiring and excellent environment.
Healthy work/life balance–you are highly engaged and productive at work because you can have time to recharge and enjoy a vibrant life outside of work.
Compensation–competitive salary. Title and salary will be commensurate with education and experience.
Excellent benefits–generous medical, dental, vision, retirement plan, paid vacation, commuter benefits, access to free shuttle transportation.
Gladstone is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, sex, religion, national origin, ancestry, age, marital status, medical condition, physical or mental disability, veteran status, sexual orientation, or any other non-job related characteristic. We make all employment decisions so as to further this principle of equal employment.
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What We Do
Gladstone's mission is to drive a new era of discovery in disease-oriented science and to mentor tomorrow’s leaders in an inspiring and diverse environment. Although Gladstone shares traits with other top life science organizations, we pride ourselves on taking uncommon scientific paths to overcoming disease. Our investigators are selected to become authorities in leading or creating new fields, and we work to provide them with resources to explore bold new thoughts, form effective scientific teams, and create or master emerging research technologies that accelerate progress—Gladstone’s special recipe for success that has yielded some of the most important biomedical advances of our time. Our three disease-focused institutes constitute the core of our discovery engine, but do not operate in isolation. We are seizing unprecedented opportunities for “convergence”—defined as the blending of intellectual and physical assets from multiple scientific disciplines and fields to speed the discovery process in our attack on unsolved health problems that affect almost every human family.
