ESSENTIAL FUNCTIONS AND RESPONSIBILITIES
- Architect and execute comprehensive lifecycle strategies that maximize the value of the asset for patients, physicians, payors, and Janux as an organization.
- Ensure alignment with corporate objectives and deliver sustained impact across the portfolio.
- Create and communicate a compelling vision for designing, conducting, and executing innovative clinical development plans through registration.
- Develop and contribute to overall strategy for specific diseases/indications, ensuring a franchise-wide portfolio perspective.
- Provide strategic insights and recommendations to optimize clinical development plans.
- Anticipate and proactively address challenges across the development continuum, including risk assessment, mitigation planning, and adaptation to evolving regulatory and competitive landscapes.
- Collaborate closely with Clinical Development, Regulatory Strategy, and Clinical Operations to deliver high-quality drug approval applications, ensuring successful regulatory outcomes and market access.
- Collaborate with cross-functional teams to continuously refine clinical strategies, leveraging translational science, real-world evidence, and stakeholder feedback to optimize program outcomes.
- Lead and develop a cross functional asset team comprised of Clinical Development, Clinical Sciences, Clinical Operations, Clinical Pharmacology, Program Management, Translational Oncology, CMC, Regulatory,and other functions as determined by the organization’s needs.
- Foster an effective, ethical, and inclusive culture that encourages teamwork, peer review, cooperation, and continuous improvement.
- Champion diversity of thought, accountability, integrity, and process excellence.
- Collaborate closely with leaders in Research, Development, Regulatory, and other key functional areas.
- Build and maintain relationships with external leaders, physicians, and patient advocacy groups.
- Be recognized internally and externally as an expert in the field, representing the organization at speaking engagements and industry forums.
- Perform other duties as assigned.
EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS AND ABILITIES
- PhD, PharmD, or other advanced degree preferred.
- Greater than 10 years of extensive clinical trial, drug development, and regulatory experience, with a strong scientific background.
- Demonstrated ability to lead through influence, managing project teams in a matrix environment rather than direct line management.
- Significant late-stage clinical development experience and exposure to different therapeutic modalities. Oncology and autoimmune experience are highly desirable.
- Domestic and international travel may be required.
Top Skills
What We Do
Janux Therapeutics is an innovative biopharmaceutical company developing next-generation therapeutics based on its proprietary Tumor Activated T Cell Engager (TRACTr) platform technology to better treat patients suffering from cancer. Janux’s initial focus is on developing a novel class of T cell engagers (TCEs), and its lead product candidates are designed to target clinically validated drug targets. While TCE therapeutics have displayed potent anti-tumor activity in hematological cancers, developing TCEs to treat solid tumors have faced challenges due to the limitations of prior TCE technologies, namely (i) overactivation of the immune system leading to cytokine release syndrome, (ii) on-target, healthy tissue toxicities, and (iii) poor pharmacokinetics leading to short half-life. Janux is using its TRACTr platform technology to engineer product candidates designed to overcome these limitations. Janux is developing a broad pipeline with lead programs targeting prostate-specific membrane antigen (PSMA), epidermal growth factor receptor (EGFR), and trophoblast cell surface antigen 2 (TROP2), with all of its programs currently in the IND-enabling or discovery stage.
