The Department of Translational Safety at Genentech provides scientific leadership and plays an active role in the process of drug development from the discovery phase through marketed products. We are seeking a Principal/Sr Principal Scientist in Toxicology to support drug development. This role will involve working in a collaborative team environment as part of the comprehensive safety assessment of Genentech therapeutics by providing toxicology representation to programs.
The successful candidate for Principal/Sr Principal Scientist will provide scientific leadership and play an active role in the process of drug development, with a strong emphasis on Genentech’s oncology and cardiovascular, respiratory, and metabolism development project portfolio, which includes small molecules, immunomodulatory biotherapeutics, bi-specific antibodies, ADCs, cancer vaccines and cellular therapeutics.
Working in a collaborative team environment, the Principal/Sr Principal Scientist leads the safety assessment of Genentech therapeutics by creating a best-evidence synthesis of existing knowledge and comprehensive investigations of toxicologic activity, strategic planning, and designing/implementing/supervising toxicology studies in support of program advancement.
The Opportunity
Interdisciplinary project team membership
Scientific leadership in the design and implementation of safety assessment strategies to support program advancement and decision-making
Preparation and review of regulatory documentation
Preparation and review of study reports and manuscripts
Representation of Genentech in meetings with regulatory authorities
Investigations into mechanisms of toxicity
Proactive management of potential safety liabilities and communication of impact to teams and governance committees.
Experience with cross-functional teams and capability to build productive cross-functional internal and external collaborations are desired.
Mentoring of toxicologists and as needed, team members, and lead or provide support to inter- and intra-departmental initiatives.
Who You Are
Principal Scientist
PhD and post-doctorate or equivalent experience in toxicology or a relevant field along with a minimum of 3+ years relevant experience in the pharmaceutical/biotechnology/CRO industry related to toxicology.
Extensive experience in drug development and interaction with global regulatory authorities are required.
Experience in oncology and cardiovascular, respiratory, and metabolism therapy areas leveraging different therapeutic modalities such as small molecules, degraders, and ADCs is highly desirable
Evidence of a consistent and extensive record of impact internally and externally.
The successful candidate must also demonstrate strong decision-making, complex problem solving, critical data analysis and interpretation, excellent written and verbal communication skills; and the ability to build productive cross-functional collaborations both within and external to Genentech
Board certification in toxicology is desirable.
The expected salary range for this position based on the primary location of California is $141,500 - $262,900.
Senior Principal Scientist
PhD and post-doctorate or equivalent experience in toxicology or a relevant field along with a minimum of 8+ years relevant experience in the pharmaceutical/biotechnology/CRO industry related to toxicology.
Extensive experience in drug development and interaction with global regulatory authorities are required.
Experience in oncology and cardiovascular, respiratory, and metabolism therapy areas leveraging different therapeutic modalities such as small molecules, degraders, and ADCs is highly desirable
Evidence of a consistent and extensive record of impact internally and externally.
The successful candidate must also demonstrate strong decision-making, complex problem solving, critical data analysis and interpretation, excellent written and verbal communication skills; and the ability to build productive cross-functional collaborations both within and external to Genentech
Board certification in toxicology is desirable.
The expected salary range for this position based on the primary location of California is $171,110 and $321,490
Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Locations
This position is based in San Francisco. This role is primarily onsite.
Relocation benefits are available.
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Skills Required
- PhD and post-doctorate or equivalent experience in toxicology or a relevant field
- Minimum 3+ years relevant industry experience in toxicology (Principal level)
- Minimum 8+ years relevant industry experience in toxicology (Senior Principal level)
- Extensive experience in drug development and interaction with global regulatory authorities
- Demonstrated decision-making, complex problem solving, critical data analysis and interpretation skills
- Excellent written and verbal communication and ability to build cross-functional collaborations
- Experience in oncology and cardiovascular, respiratory, and metabolism therapy areas and with modalities such as small molecules, degraders, ADCs, biotherapeutics, vaccines, or cellular therapeutics
- Evidence of a consistent and extensive record of impact internally and externally
- Mentoring experience of toxicologists or team members and leadership of cross-departmental initiatives
- Board certification in toxicology
Genentech Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Genentech and has not been reviewed or approved by Genentech.
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Healthcare Strength — Health coverage is described as comprehensive across medical, dental, vision, mental health, and prescriptions, supported by HSAs/FSAs and broad wellness resources. On‑site fitness and health centers, mental‑health clinicians, and specialized programs like fully covered preventive cancer screenings and menopause support deepen the offering.
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Retirement Support — Retirement benefits feature a 401(k) with up to a 4% company match plus an additional annual 6% company contribution to eligible pay. Additional financial protections such as life and accident insurance complement salary, bonuses, and stock options.
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Leave & Time Off Breadth — Time away includes about 20 paid vacation days, paid holidays, personal days, and a year‑end shutdown. A paid six‑week sabbatical every six years notably expands long‑term time‑off flexibility.
Genentech Insights
What We Do
Considered the founder of the industry, Genentech, now a member of the Roche Group, has been delivering on the promise of biotechnology for more than 40 years. Genentech is a biotechnology company dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. We're passionate about finding solutions for people facing the world's most difficult-to-treat conditions. That is why we use cutting-edge science to create and deliver innovative medicines around the globe. To us, science is personal. Making a difference in the lives of millions starts when you make a change in yours.
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