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The successful Translational Safety Principal Pathologist candidate will provide scientific leadership and play an active role in the process of drug development from target assessment through marketed products. Working in a team environment, Translational Safety Project Pathologists participate in and may lead the strategic design, implementation, and data analysis of non-GLP investigative and GLP regulatory studies to ensure the comprehensive, highly integrated safety profiling of Genentech drug candidates.
The Opportunity
The responsibilities of this Principal Scientist project pathologist position will include:
Provide veterinary clinical, technical, and scientific expertise on in-house and CRO-based studies from protocol development through necropsy, clinical pathology, and histopathology evaluations, pathology peer review and final report generation.
Collaborate closely with toxicologists and study operations professionals, providing expertise in the development of streamlined, innovative safety assessment programs for Genentech drug candidates.
Work independently to leverage literature to develop and optimize best-evidence arguments in support of data interpretation or experimental approaches.
Lead or coauthor high quality scientific manuscripts and regulatory documents, and represent Genentech/Roche in meetings with regulatory authorities to influence toxicologic pathology and industry standards in drug development.
Collaborate with in vitro systems scientists to characterize and qualify assays for assessment of toxicity.
Design and conduct in vitro and/or in vivo investigative and mechanistic studies in collaboration with toxicologists and subject matter experts.
Advance applications of digital pathology for greater scientific insights and workflow efficiencies.
Participate in the therapeutic area focused Expert Working Groups.
Participate in and lead interdisciplinary project teams.
Provide functional area mentorship and leadership in Pathology.
Perform managerial, administrative, tactical, or strategic roles within Translational Safety, Development Sciences, or gRED, commensurate with experience.
Who You Are:
A DVM/VMD, or equivalent, and board certification in the American College of Veterinary Pathology or European College of Veterinary Pathology.
PhD in Integrative Pathobiology, or related discipline, preferred. Alternatively, a minimum of 5 years of relevant industry experience
Relocation Assistance benefits are not available for this posting.
The expected salary range for this position based on the primary location of San Franscico, CA is $181,200 - $336,400 Annual. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.
This position also qualifies for the benefits detailed here:
Benefits
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Skills Required
- DVM or VMD (or equivalent)
- Board certification in American College of Veterinary Pathology (ACVP) or European College of Veterinary Pathology (ECVP)
- PhD in Integrative Pathobiology or related discipline
- Minimum of 5 years relevant industry experience
- Experience with GLP and non-GLP regulatory toxicology studies
- Proficiency in necropsy, clinical pathology, histopathology evaluations, and pathology peer review
- Experience designing and conducting in vitro and/or in vivo investigative and mechanistic studies
- Experience or willingness to apply and advance digital pathology
Genentech Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Genentech and has not been reviewed or approved by Genentech.
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Healthcare Strength — Health coverage is described as comprehensive across medical, dental, vision, mental health, and prescriptions, supported by HSAs/FSAs and broad wellness resources. On‑site fitness and health centers, mental‑health clinicians, and specialized programs like fully covered preventive cancer screenings and menopause support deepen the offering.
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Retirement Support — Retirement benefits feature a 401(k) with up to a 4% company match plus an additional annual 6% company contribution to eligible pay. Additional financial protections such as life and accident insurance complement salary, bonuses, and stock options.
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Leave & Time Off Breadth — Time away includes about 20 paid vacation days, paid holidays, personal days, and a year‑end shutdown. A paid six‑week sabbatical every six years notably expands long‑term time‑off flexibility.
Genentech Insights
What We Do
Considered the founder of the industry, Genentech, now a member of the Roche Group, has been delivering on the promise of biotechnology for more than 40 years. Genentech is a biotechnology company dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. We're passionate about finding solutions for people facing the world's most difficult-to-treat conditions. That is why we use cutting-edge science to create and deliver innovative medicines around the globe. To us, science is personal. Making a difference in the lives of millions starts when you make a change in yours.
