- Lead the design, execution, and interpretation of preclinical pharmacology studies supporting drug discovery and development programs
- Develop and apply quantitative PK/PD models, integrating pharmacokinetics, pharmacodynamics, and chemical kinetics to guide compound optimization and dosing strategies
- Design and oversee in vivo studies, including selection and development of appropriate animal models
- Drive rigorous data analysis, including statistical evaluation and modeling to inform decision-making
- Translate preclinical findings into clinically relevant hypotheses and development strategies
- Collaborate closely with teams to optimize drug candidates and delivery systems
- Contribute to regulatory documentation and strategy (IND-enabling studies, study reports, etc.)
- Build and manage relationships with CROs and external collaborators
Qualifications
- PhD, MD, or equivalent in pharmacology, biomedical sciences, or related field
- Significant experience in preclinical pharmacology within biotech or pharmaceutical settings
- Experience in choosing appropriate animal models
- Deep expertise in PK/PD modeling, with strong grounding in chemical kinetics and quantitative biology
- Proven experience designing studies to evaluate drug combinations and synergy, including application of factorial experimental design Demonstrated experience designing and interpreting in vivo pharmacology studies
- Experience in advancing preclinical candidates through IND-enabling studies and contributing meaningfully to IND submissions
- Strong statistical and data analysis skills
- Experience in metabolic diseases, particularly obesity and/or diabetes, strongly preferred
Skills Required
- PhD, MD, or equivalent in pharmacology, biomedical sciences, or related field
- Significant experience in preclinical pharmacology within biotech or pharmaceutical settings
- Experience in choosing appropriate animal models
- Deep expertise in PK/PD modeling, strong grounding in chemical kinetics and quantitative biology
- Proven experience designing studies to evaluate drug combinations and synergy, including application of factorial experimental design
- Demonstrated experience designing and interpreting in vivo pharmacology studies
- Experience in advancing preclinical candidates through IND-enabling studies and contributing meaningfully to IND submissions
- Strong statistical and data analysis skills
- Experience in metabolic diseases, particularly obesity and/or diabetes
What We Do
5AM was founded in 2002 and pursues investments in advanced life science innovations, and seeks to be diversified across the biopharmaceutical therapeutics, and platform technologies. Within each sector, 5AM invests across multiple therapeutic areas and modalities and evaluates opportunities based on innovative platform technologies, corporate spin-offs and products with shorter development cycles. Content 5AM shares on this platform is not, and may not be relied on, in any manner, as legal, tax, investment, accounting or other advice or as an offer to sell or a solicitation of an offer to buy an interest in any private fund, special purpose or other investment vehicle sponsored by 5AM Ventures. Content 5AM shares on this platform is not an investment recommendation. For a full list of all 5AM portfolio companies, please visit: https://5amventures.com/portfolio/
