Cellares

Principal SAP Technical Architect, GMP Systems

Reposted 3 Days Ago

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2 Locations

In-Office

90K-250K Annually

Expert/Leader

Biotech

The Role

The Principal SAP Technical Architect will be responsible for the design, development, and support of SAP systems in a GMP environment, engaging in ABAP programming, Fiori development, and integration with middleware platforms while collaborating with cross-functional teams.

Summary Generated by Built In

We are seeking a highly motivated and hands-on Principal SAP Technical Architect, GMP Systems to play a key role in enabling the technology foundation for a state-of-the-art, multi-product cell therapy manufacturing facility. This role will be directly responsible for the technical design, development, integration, and support of SAP systems and middleware platforms critical to GMP manufacturing operations.

As a senior individual contributor, this role will focus on SAP architecture and development, including ABAP programming, Fiori applications, SAP Basis, and Security configuration, as well as integration with external systems through middleware platforms such as MuleSoft and Workato. The role requires deep hands-on expertise across the SAP technology stack and experience supporting enterprise-grade manufacturing, quality, and supply chain systems in a regulated GMP environment.

This is a highly technical role that requires close collaboration with cross-functional teams including Operations, MS&T, Quality, Supply Chain, Engineering, and IT. The ideal candidate will be comfortable working in a fast-paced, mission-driven environment and capable of translating business needs into scalable, compliant, and supportable technical solutions.

Responsibilities

Serve as a hands-on technical expert across SAP systems, actively engaging in ABAP programming, Fiori app development, SAP Basis administration, and SAP Security roles and authorizations
Participate in design, development, debugging, performance tuning, and deployment activities to ensure stable, secure, and scalable solutions
Develop and maintain a comprehensive technical blueprint for GMP systems, aligning technology services with business objectives and regulatory requirements
Provide architectural leadership in resolving inter-program and inter-project issues related to GMP systems
Partner with the IDMO Business to develop and execute against an IT roadmap and deliver on the IT infrastructure needed to manufacture autologous and allogeneic cell therapy products
Work closely with Validation and Quality in deploying and supporting IT GMP Systems
Manage and coordinate employees, contractors, and agencies involved in development projects to ensure alignment with project goals, timelines, budgets, and quality standards
Establish KPIs, monitor progress, and keep critical stakeholders informed of progress for IT projects and strategic initiatives
Establish key stakeholder relationships with internal and external stakeholders
Work closely with other functional areas to develop and execute against the strategic plan for all Cellares sites
Serve as a subject matter expert (SME) during audits or inspections by regulatory authorities

Requirements

Bachelor’s degree in Computer Science or a related technical field
Minimum of 10+ years of experience within IT in a cGMP environment in the biotech/biopharma industry, including at least 5 years of leadership or lead developer experience
Strong, hands-on experience in SAP development, including ABAP programming, Fiori/UI5 app development, and related SAP technology stacks
Experience in interface development and management using platforms such as MuleSoft, Workato, or similar integration tools
Experience implementing and supporting Manufacturing, Quality, and Supply Chain applications, including ERP, MES, LIMS, QMS, etc.
Ability to manage shifting priorities to meet critical deadlines in a fast-paced and dynamic environment while maintaining clarity of focus
Proven ability to deliver results independently with a proactive, hands-on approach to technical problem solving
Demonstrated success in building scalable, compliant, and supportable GMP systems with minimal supervision
Strong analytical and critical thinking skills with a detail-oriented mindset
Excellent teamwork and interpersonal skills; ability to communicate technical concepts to non-technical stakeholders
Strong written and verbal communication skills
Self-motivated with a passion for technology and continuous learning
Self-awareness, integrity, authenticity, and a growth mindset

This is Cellares

Cellares is the first Integrated Development and Manufacturing Organization (IDMO) and takes an Industry 4.0 approach to mass manufacturing the living drugs of the 21st century. The company is both developing and operating integrated technologies for cell therapy manufacturing to accelerate access to life-saving cell therapies. The company’s Cell Shuttle integrates all the technologies required for the entire manufacturing process in a flexible and high-throughput platform that delivers true walk-away, end-to-end automation. Cell Shuttles will be deployed in Cellares’ Smart Factories around the world to meet total patient demand for cell therapies at global scale. Partnering with Cellares enables academics, biotechs, and pharma companies to accelerate drug development and scale out manufacturing, lower process failure rates, lower manufacturing costs, and meet global patient demand.

The company is headquartered in South San Francisco, California with its commercial-scale IDMO Smart Factory in Bridgewater, New Jersey. The company is backed by world-class investors and has raised over $355 million in financing.

Leveling will be based on overall experience, education, and demonstration of knowledge throughout the interview process.

Top Skills

Abap

Erp

Fiori

Lims

Mes

Mulesoft

Qms

SAP

Sap Basis

Sap Security

Workato

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The Company

HQ: South San Francisco, CA

109 Employees

Year Founded: 2019

What We Do

Cellares is revolutionizing cell therapy manufacturing. We are developing a one-of-a-kind solution, The Cell Shuttle, to overcome the challenges associated with manufacturing so these life-saving therapies are affordable and widely available to patients who can benefit.

The clinical impact of cell therapy in treating cancer has been proven, but this therapeutic approach has several limitations, especially in manufacturing, leaving extremely sick patients waiting for treatment and desperate for hope.
Since cell therapy is currently produced for a single patient at a time, it is expensive to manufacture, requiring significant time and resources, and is difficult to scale.

Preclinical and clinical scientists, as well as commercial cell therapy manufacturers also lack the options to fully automate their manufacturing process quickly, safely, cost-effectively and at the scale they need.

The Cell Shuttle is an automated and closed end-to-end manufacturing solution that is flexible and scalable, enabling customers to run exact processes specified for their cell therapy. Compared with the current manual manufacturing processes for cell therapy, the Cell Shuttle’s next-generation automated manufacturing solution has 10 times the scalability (meaning 10 times more patient doses can be produced simultaneously), enables a three-fold reduction in process failure rates and will reduce the per-patient manufacturing cost by up to 70 percent for most processes.