Welcome to the Roche/Genentech global Drug Substance manufacturing network. Our purpose is to guide Drug Substance network priorities, advance value delivery through solution and project management excellence, and govern compliance to strengthen our impact on the wider organization. We are simultaneously navigating a critical phase of digital transformation to ensure the reliable supply and enhanced performance of our drug substance sites.
Are you a problem-solver and change-agent who thrives in a matrix team environment, eager to tackle complex organizational and technical challenges? If so, this is a unique opportunity to shape the future of our network, ensuring a future-ready operation that accelerates delivery, unlocks capacity, and unifies our automation landscape to meet modern user expectations.
The Opportunity
The Principal Program Manager role leads the planning, integration, and execution of complex, cross-functional initiatives within our global network. In this dynamic role, you will act as the primary driver for delivering large-scale initiatives, ensuring strong governance, prioritization, and clear trade-off decisions to deliver high-impact benefits.
You will collaborate closely with program teams, sites and functions to ensure alignment between strategic objectives and execution. You will lead initiatives focusing on our core program objectives:
Operational Excellence & Strategic Delivery: You will drive initiatives to optimize performance, ensure consistent delivery of objectives, and build detailed scenarios to keep program timelines on track.
Business Agility & Transformation: You will architect project strategies to ensure our capabilities are seamlessly prepared to support new product launches, business expansions, and market changes.
Process Optimization & Infrastructure Planning: You will manage projects aimed at optimizing internal capacity and reducing operational downtime. You will also plan for long-term strategic infrastructure changes, such as major automation layer upgrades (e.g., MES-DCS integration) and ensuring adherence to multi-year system lifecycle deadlines.
Value Creation: You will support continuous improvement and cost-optimization initiatives that generate sustainable savings to reinvest in new asset development and capability enhancements.
Who you are
You have a Bachelor's Degree or above, preferably in Engineering, Business or a related field.
You have at least 8 years of successful experience in the Biotech/Pharmaceutical or a complex matrix-driven industry, managing highly complex projects such as cross-functional business transformation and infrastructure migrations.
You have experience in scoping, planning, and leading cross-functional project teams’ execution of diverse projects, with a wide range of levels of complexity, technical and/or business-related.
Preferred Qualifications
You have a graduate degree or certification in Project Management (i.e., PMI certification)
You have a strong ability for strategic analysis, translating opportunities into concrete execution plans via highly structured methodologies.
You have exceptional influencing capabilities, interpersonal and broad communication skills, negotiation, collaboration, and strategic problem-solving abilities, alongside excellent time management and organizational skills.
You have a demonstrated ability to lead with and without functional direct-line authority, effectively engaging key Stakeholders.
You understand and advocate for Safety, Quality, Delivery, Engagement, and Cost to assure that the projects meet or exceed all corporate guidelines.
The expected salary range for this position based on the primary location for this position of South San Francisco, CA is $135,800 - $252,200. Actual pay will be determined based on experience, level, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Link to Benefits
Relocation benefits are provided
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Skills Required
- Bachelor’s degree or higher, preferably in Engineering, Business, or a related field
- At least 8 years of successful experience in biotech, pharmaceutical, or another complex matrix-driven industry
- Experience managing highly complex projects, including cross-functional business transformation and infrastructure migrations
- Experience scoping, planning, and leading cross-functional project teams through execution of diverse technical and business projects
- Graduate degree or project management certification, such as PMI certification
- Ability to perform strategic analysis and translate opportunities into structured execution plans
- Exceptional influencing, communication, negotiation, collaboration, strategic problem-solving, time management, and organizational skills
- Ability to lead with and without direct functional authority and effectively engage stakeholders
- Understanding of and commitment to Safety, Quality, Delivery, Engagement, and Cost objectives
Genentech Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Genentech and has not been reviewed or approved by Genentech.
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Healthcare Strength — Health coverage is described as comprehensive across medical, dental, vision, mental health, and prescriptions, supported by HSAs/FSAs and broad wellness resources. On‑site fitness and health centers, mental‑health clinicians, and specialized programs like fully covered preventive cancer screenings and menopause support deepen the offering.
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Retirement Support — Retirement benefits feature a 401(k) with up to a 4% company match plus an additional annual 6% company contribution to eligible pay. Additional financial protections such as life and accident insurance complement salary, bonuses, and stock options.
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Leave & Time Off Breadth — Time away includes about 20 paid vacation days, paid holidays, personal days, and a year‑end shutdown. A paid six‑week sabbatical every six years notably expands long‑term time‑off flexibility.
Genentech Insights
What We Do
Considered the founder of the industry, Genentech, now a member of the Roche Group, has been delivering on the promise of biotechnology for more than 40 years. Genentech is a biotechnology company dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. We're passionate about finding solutions for people facing the world's most difficult-to-treat conditions. That is why we use cutting-edge science to create and deliver innovative medicines around the globe. To us, science is personal. Making a difference in the lives of millions starts when you make a change in yours.
