Why Genentech
We’re passionate about delivering on Our Promise to improve the lives of patients and create healthier communities for all. We foster a culture of inclusivity, integrity and creativity while boldly pursuing answers to the world’s most complex health challenges and transforming society.
The Position
The Principal Program Manager, Process Safety & Risk is a hands-on, strategic position responsible for the development, implementation, and continuous improvement of process safety and EHS risk management programs that protect people, our pipeline, and our right to operate. As a highly experienced engineer, you will combine subject-matter expertise with the ability to communicate, influence, and provide practical in-the-field solutions to real-world problems to help achieve our aspiration toward zero injuries and illnesses.
The Opportunity
The Principal Program Manager, Process Safety & Risk will apply advanced theoretical knowledge and contribute to the development of new principles and concepts to independently address unusually complex or strategic problems. To excel in this position, the ideal candidate will possess 8+ years of progressive experience and a unique blend of strong technical expertise, exceptional leadership skills, and strategic agility.
Key Responsibilities
Drive a multi-year Process Safety and SHE Risk Management strategy that directly aligns with the site’s mission to deliver life-saving drug substances.
Exercise high-level autonomy and independent judgment to shape the organization's long-range goals and significant strategic outcomes.
Lead root-cause analysis and complex incident investigations, applying innovative engineering solutions to ensure a path toward zero injuries and illnesses.
Ensure strict adherence to Roche Corporate SHE Directives (including K3 and K9) by developing and continuously improving comprehensive risk management programs.
Serve as the primary cross-functional liaison, effectively partnering with manufacturing, engineering, production services, warehouse, and quality teams in addition to contractors and service providers to ensure the successful execution of site-wide safety initiatives.
Act as a key organizational spokesperson, synthesizing complex technical data into clear, persuasive messages to influence stakeholders and drive policy adoption.
Champion operational efficiency by managing budgets, schedules, and change management efforts that reframe safety challenges into sustainable business opportunities.
Who You Are
Bachelor’s degree in chemical, mechanical, civil, or electrical engineering. Certification as a registered professional engineer is preferred, but not required.
8+ years of relevant work experience in SHE program management, process safety engineering, or risk management. Prior experience in the Biotechnology and Pharmaceutical industries or high-hazard environments is preferred.
Extensive "hands-on" experience in leading process safety reviews, conducting safety risk assessments, and developing strategic control solutions using engineering and administrative controls. Extensive in-the-field experience conducting incident investigations and root-cause analysis.
Thorough knowledge of environment, health, and safety regulations, codes, and standards, including Cal/OSHA, OSHA, EPA, NIOSH, Cal/ARP, and local CUPA requirements.
Excellent teamwork skills with the ability to effectively lead, facilitate, and motivate cross-functional and interdepartmental agile teams in a fast-paced environment.
Location
This position is based in South San Francisco, CA campus
Relocation assistance is not available at this time.
The expected salary range for this position based on the primary location of South San Francisco, CA is $138,500.00- 257,100.00 USD. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Skills Required
- Bachelor's degree in chemical, mechanical, civil, or electrical engineering
- 8+ years relevant experience in SHE program management, process safety engineering, or risk management
- Hands-on experience leading process safety reviews and conducting safety risk assessments
- Extensive in-field experience conducting incident investigations and root-cause analysis
- Knowledge of EHS regulations, codes, and standards (Cal/OSHA, OSHA, EPA, NIOSH, Cal/ARP, local CUPA)
- Ability to lead, facilitate, and motivate cross-functional and interdepartmental teams
- Experience managing budgets, schedules, and change management related to safety initiatives
- Ability to synthesize complex technical data and influence stakeholders as an organizational spokesperson
- Certification as a registered professional engineer (PE)
- Prior experience in Biotechnology/Pharmaceutical industries or high-hazard environments
Genentech Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Genentech and has not been reviewed or approved by Genentech.
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Healthcare Strength — Health coverage is described as comprehensive across medical, dental, vision, mental health, and prescriptions, supported by HSAs/FSAs and broad wellness resources. On‑site fitness and health centers, mental‑health clinicians, and specialized programs like fully covered preventive cancer screenings and menopause support deepen the offering.
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Retirement Support — Retirement benefits feature a 401(k) with up to a 4% company match plus an additional annual 6% company contribution to eligible pay. Additional financial protections such as life and accident insurance complement salary, bonuses, and stock options.
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Leave & Time Off Breadth — Time away includes about 20 paid vacation days, paid holidays, personal days, and a year‑end shutdown. A paid six‑week sabbatical every six years notably expands long‑term time‑off flexibility.
Genentech Insights
What We Do
Considered the founder of the industry, Genentech, now a member of the Roche Group, has been delivering on the promise of biotechnology for more than 40 years. Genentech is a biotechnology company dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. We're passionate about finding solutions for people facing the world's most difficult-to-treat conditions. That is why we use cutting-edge science to create and deliver innovative medicines around the globe. To us, science is personal. Making a difference in the lives of millions starts when you make a change in yours.
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