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Job Description
Job Description
Gilead Sciences is seeking a creative and highly motivated Postdoctoral Research Fellow to join the Analytical Development organization. This role will focus on developing nextgeneration spectromicroscopy strategies (Raman, FTIR, OPTIR, MALDI MS,) to characterize longacting injectable (LAI) drug depots and understand their intissue chemical and solidstate behavior.
This position provides a unique opportunity to integrate advanced spectroscopy, multimodal imaging, chemometrics, and machine learning to address key scientific questions related to drug release, depot stability, and injectionsite responses.
Responsibilities The Postdoctoral Fellow will:
Develop and optimize Raman, FTIR, OPTIR, and MALDI MS methods to characterize depot chemistry and solidstate forms across synthetic media and exvivo tissues.
Perform stressinduced solid form transition studies (pH, oxidative stress, moisturedriven transformations) for model LAI systems.
Build machinelearning and chemometric models (CLS, PLS, PCA, imagebased segmentation) to map drug distribution, degradation, and polymorphic transitions.
Characterize drug depots in porcine dermis, fat, and muscle tissue to assess intissue transformations and correlate analytical findings with histopathology and ISR outcomes.
Integrate multimodal datasets (Raman/IR/MALDI) into unified chemical imaging workflows to support formulation development.
Collaborate closely with Formulation, DMPK, DPP, and Toxicology teams on crossfunctional LAI development.
Present research in internal forums and contribute to highimpact external publications and conferences.
Required Qualifications
PhD in Chemistry, Chemical Engineering, Pharmaceutical Sciences, Materials Science, Optics Science, Biomedical Engineering, Mechanical Engineering or related discipline.
Hands on experience with Raman and/or FTIR spectroscopy.
Proficiency in Python and/or MATLAB for spectroscopic data processing,multivariate analysis, and deep learning for image segmentation.
Strong scientific curiosity, problemsolving ability, and independent research skills.
Demonstrated track record of conference presentations or peerreviewed publications.
Preferred Qualifications
Experience with techniques such as OPTIR, digital microscopy, fluorescence microscopy, quantitative phase microscopy, SEM/EDS, XRPD, MALDIIMS, HPLC, LCMS.
Experience with building and maintaining advanced or non-linear spectroscopy/microscopy instruments.
Background in solidstate characterization, LAI formulation, or tissuebased imaging workflows.
Familiarity with chemometric platforms (e.g., PLS Toolbox).
Excellent communication skills and ability to work in a matrixed, multidisciplinary environment.
For additional benefits information, visit:
https://www.gilead.com/careers/compensation-benefits-and-wellbeing
* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.
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The way we see it, the impossible is not impossible. It’s simply what hasn’t been achieved yet. For more than 30 years, we’ve pursued it, chased it down, tackled it for answers and surrounded it for a way in. We have worked tirelessly to bring forward medicines for life-threatening diseases.
Creating Possible drives everything we do. It’s evident in our mission and core values. This is how we built a culture of excellence that is fueled by a passion for improving lives of people around the world.
For us, nothing is impossible – because of the people we work with, the communities we stand with and the partners we push forward with. Our ~12,000 employees band together through science, grit, compassion and courage to prove the impossible wrong.
At Gilead, the tangible results of your contributions are evident. Where every individual matters. Where all employees can enhance their skills through ongoing development. And where we start every day with one question: “What’s next?”
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