Janux Therapeutics is seeking a highly organized and proactive Manager, Project Management Operations, to support our expanding portfolio of oncology and autoimmune programs. This individual will serve as a key operational partner to the Program Management and Clinical Operations organizations by driving project planning, maintaining integrated development timelines, and leading the implementation and optimization of Smartsheet across cross-functional teams.
The ideal candidate combines deep expertise in project management systems, particularly Smartsheet, with hands-on experience supporting oncology and autoimmune drug development programs through critical milestones, including IND submissions and early clinical development. This role offers an opportunity to help establish scalable project management infrastructure while contributing directly to the advancement of innovative therapies for patients.
ESSENTIAL FUNCTIONS AND RESPONSIBILITIES
- Serve as the internal Smartsheet subject matter expert and primary administrator.
- Lead implementation, configuration, and optimization of Smartsheet across Program Management, Clinical Operations, CMC, and other development functions.
- Design, build, and maintain project plan templates, dashboards, reports, and automated workflows.
- Drive standardization of project planning processes and reporting methodologies across programs.
- Design, build, and optimize automated reporting systems for program and clinical study metrics, improving data accuracy, visibility, and operational efficiency
- Provide training, support, and best practices to end users throughout the organization.
- Develop, maintain, and continuously improve integrated cross-functional project plans supporting programs.
- Partner with Program Management, Clinical Operations, Regulatory Affairs, CMC, Translational Sciences, and other functional teams to ensure project timelines accurately reflect program strategies, deliverables, dependencies, and milestones.
- Monitor critical path activities, identify schedule risks, and proactively escalate potential timeline impacts.
- Support planning and execution activities associated with regulatory submissions, including IND-enabling activities and IND submissions.
- Support program teams through meeting coordination, action item tracking, risk management, and milestone monitoring.
- Contribute to the development and continuous improvement of project management tools, processes, and governance practices.
- Provide operational support for candidate nomination, IND planning, and early clinical development activities.
- Support alliance and partnership activities, as applicable.
- Other duties as deemed necessary.
Smartsheet Implementation & Administration
Project Planning & Timeline Management
Program Operations Support
EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS, AND ABILITIES
- Bachelor's degree in a life sciences, scientific, engineering, or related field.
- 5+ years of project management, program operations, clinical operations, regulatory operations, or related experience within biotechnology or pharmaceutical drug development.
- Demonstrated experience supporting oncology and/or autoimmune development programs.
- Hands-on experience supporting IND submissions and early-stage drug development programs.
- Advanced expertise with Smartsheet, including implementation, customization, workflow automation, dashboard creation, and project plan development.
- Experience building and maintaining integrated cross-functional development timelines.
- Strong understanding of drug development processes across Regulatory, Clinical Operations, CMC, and Translational functions.
- Excellent organization, communication, and stakeholder management skills.
- Ability to thrive in a fast-paced, evolving biotech environment.
Skills Required
- Bachelor's degree in life sciences, scientific, engineering, or related field
- 5+ years project management, program operations, clinical operations, regulatory operations, or related experience within biotechnology or pharmaceutical drug development
- Demonstrated experience supporting oncology and/or autoimmune development programs
- Hands-on experience supporting IND submissions and early-stage drug development programs
- Advanced expertise with Smartsheet including implementation, customization, workflow automation, dashboards, and project plan development
- Experience building and maintaining integrated cross-functional development timelines
- Strong understanding of drug development processes across Regulatory, Clinical Operations, CMC, and Translational functions
- Excellent organization, communication, and stakeholder management skills
- Authorized to work in the United States
- Ability to work on site in San Diego, CA
What We Do
Janux Therapeutics is an innovative biopharmaceutical company developing next-generation therapeutics based on its proprietary Tumor Activated T Cell Engager (TRACTr) platform technology to better treat patients suffering from cancer. Janux’s initial focus is on developing a novel class of T cell engagers (TCEs), and its lead product candidates are designed to target clinically validated drug targets. While TCE therapeutics have displayed potent anti-tumor activity in hematological cancers, developing TCEs to treat solid tumors have faced challenges due to the limitations of prior TCE technologies, namely (i) overactivation of the immune system leading to cytokine release syndrome, (ii) on-target, healthy tissue toxicities, and (iii) poor pharmacokinetics leading to short half-life. Janux is using its TRACTr platform technology to engineer product candidates designed to overcome these limitations. Janux is developing a broad pipeline with lead programs targeting prostate-specific membrane antigen (PSMA), epidermal growth factor receptor (EGFR), and trophoblast cell surface antigen 2 (TROP2), with all of its programs currently in the IND-enabling or discovery stage.
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