Senior Forward Deployed Engineer

As the amount of biomedical data types and scale continues to grow, old ways of working with data hold back the pace of progress — fragmented data, overwhelming omics, complex manual work, analysis backlogs, friction in secure collaboration, and barriers to distributing workflows. We have a conviction about how to move closer to a future of precision medicine by making it ten times faster and one-tenth the cost to generate knowledge, develop better treatments, and improve patient outcomes.

As a result, Manifold began its journey. We’re a health research infrastructure company that enables researchers to focus on the high-impact research that matters most, by taking care of all the other stuff that gets in the way. As a trusted research platform for modern scientific collaboration, we partner with top-tier healthcare providers, life sciences organizations, and research institutions to unlock real-world data and deliver actionable insights that improve precision medicine and discovery.

We’re currently a Series A startup with 50+ employees across North America. Backed by top-tier investors and healthcare leaders including; Andrew Marks of TQ Ventures, Jason Schoettler of Calibrate Ventures, Gaurav Singal of Foundation Medicine, Steve Fredette of Toast, Amar Kendale of Livongo, Andrew Bialecki of Klaviyo, Brad Porter of Amazon, Jon Karlen of Acadian Software, and Pravin Soni of Elevation Pharma.

At Manifold, we value intellectual rigor, humility, and mission-driven collaboration. We believe that technology is only as powerful as the people behind it, and we’re building a culture that supports growth, inclusion, and curiosity. We work fast, think deeply, and strive to make a lasting impact on patients' lives.

As the amount of biomedical data types and scale continues to grow, old ways of working with data hold back the pace of progress — fragmented data, overwhelming omics, complex manual work, analysis backlogs, friction in secure collaboration, and barriers to distributing workflows.

Manifold is a health research infrastructure company that enables researchers to focus on the high-impact research that matters most, by taking care of all the other stuff that gets in the way. As a trusted research platform for modern scientific collaboration, we partner with top-tier healthcare providers, life sciences organizations, and research institutions to unlock real-world data and deliver actionable insights that improve precision medicine and discovery.

We’re a Series B funded startup with over 50 employees across North America, backed by world-class investors and healthcare leaders including Andrew Marks of TQ Ventures, Jason Schoettler of Calibrate Ventures, Gaurav Singal of Foundation Medicine, Steve Fredette of Toast, Amar Kendale of Livongo, Andrew Bialecki of Klaviyo, Brad Porter of Amazon, Jon Karlen of Acadian Software, and Pravin Soni of Elevation Pharma.

As a Forward Deployed Engineer (FDE), you will sit at the intersection of engineering, product, and customer success. You’ll work directly with our life sciences and healthcare partners to deploy Manifold’s platform in real-world environments, tailoring solutions to their unique needs.

This role is ideal for engineers who thrive in fast-paced, customer-facing environments—someone who loves solving complex problems hands-on, bridging the gap between platform engineering and applied use cases in genomics, oncology, and clinical research.

• Own deployments of the Manifold platform at customer sites, ensuring seamless integration with existing data systems and workflows.

• Collaborate with researchers, data scientists, and clinical teams to translate their problems into scalable technical solutions.

• Implement, customize, and optimize pipelines for multimodal data (EHR, genomics, imaging, clinical data).

• Act as the technical voice of the customer, bringing feedback into Manifold’s product roadmap.

• Troubleshoot and resolve technical challenges across cloud infrastructure, data ingestion, and security/compliance environments.

• Partner closely with engineering and product teams to ensure deployments are scalable, reproducible, and production-ready.

• Create technical documentation and best practices to enable repeatable deployments across institutions.

• 5+ years of professional experience in software engineering, data engineering, or related technical roles.

• Strong proficiency with Python, SQL, and cloud infrastructure (GCP preferred).

• Experience working with healthcare, life sciences, or other regulated data environments a strong plus.

• Comfort navigating both technical and non-technical conversations with researchers, clinicians, and IT stakeholders.

• Ability to work independently in dynamic, customer-facing situations while maintaining strong collaboration with internal teams.

• Enthusiasm for working in a startup environment where adaptability, curiosity, and ownership are key.

• Fully supported remote work across North American time zones.

• Comprehensive benefits: healthcare, dental, vision, life insurance, disability.

• 401k match, 12 weeks parental leave, commuter benefits (for those working in Newton, MA office).

• Renters & pet insurance, pharmacy discounts.

• A culture that values curiosity, transparency, and impact.

We are a team of proven startup operators with a track record of building successful technology companies, and deep subject matter expertise across oncology, clinical, precision medicine, enterprise SaaS, and healthcare technology.

We’re still a startup—some things are unstructured, and we like it that way. We value adaptability, ownership, and an eagerness to jump in wherever needed to move the mission forward.