The Opportunity
We are seeking a talented Principal Scientist (Group Leader) to join the Department of Antibody Engineering in Genentech Research and Development (gRED), where we discover and engineer life-changing antibody drugs through pioneering science and technology. The successful candidate will lead a group to collaboratively develop bi/multi-specific antibodies by building new technologies and workflows to advance future internal antibody drug discovery programs and identify lead clinical candidates.
Primary responsibilities will focus on three areas.
Engage with therapeutic areas to design and apply new antibody MOAs at the interface of biology and molecular engineering
Leverage structure-based engineering and internal AI/ML capabilities to design novel molecule formats
Serve as molecule or project team leader to direct therapeutic antibody lead selection, optimization, and engineering to develop best- or first-in-class antibody therapeutics
The individual should be passionate about developing creative and innovative protein-based technologies using skills in protein engineering, structural biology, biochemistry, or molecular biology. Exceptionally strong leadership and communications skills are essential for the position as the individual is expected to collaborate across Antibody Engineering to discover and advance next generation therapeutics.
Who You Are
Ph.D. in a biological science plus post doc experience, including at least 4 years of recent protein engineering and/or antibody engineering in academia, biotechnology and/or pharma.
Strong background in protein engineering, molecular biology techniques, and/or structural biology is required.
Solid record of accomplishments and publications as evidence of scientific knowledge.
Deep commitment to working as part of teams.
Strong communication and leadership skills.
Preferred
Experience with engineering bi- or multi-specific antibody/protein formats is preferred.
Experience with structure-based protein analysis is a plus.
Relocation benefits are available for this posting.
The expected salary range for this position based on the primary location of California is $143,200 to $265,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
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#gRED
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Genentech Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Genentech and has not been reviewed or approved by Genentech.
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Healthcare Strength — Health coverage is described as comprehensive across medical, dental, vision, mental health, and prescriptions, supported by HSAs/FSAs and broad wellness resources. On‑site fitness and health centers, mental‑health clinicians, and specialized programs like fully covered preventive cancer screenings and menopause support deepen the offering.
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Retirement Support — Retirement benefits feature a 401(k) with up to a 4% company match plus an additional annual 6% company contribution to eligible pay. Additional financial protections such as life and accident insurance complement salary, bonuses, and stock options.
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Leave & Time Off Breadth — Time away includes about 20 paid vacation days, paid holidays, personal days, and a year‑end shutdown. A paid six‑week sabbatical every six years notably expands long‑term time‑off flexibility.
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What We Do
Considered the founder of the industry, Genentech, now a member of the Roche Group, has been delivering on the promise of biotechnology for more than 40 years. Genentech is a biotechnology company dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. We're passionate about finding solutions for people facing the world's most difficult-to-treat conditions. That is why we use cutting-edge science to create and deliver innovative medicines around the globe. To us, science is personal. Making a difference in the lives of millions starts when you make a change in yours.
