Title: Executive Director, DMPK
Location: Exton, PA
Reports to: VP, DMPK
Frontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China, and growing over 30% YOY. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.
Position/Job Summary:
The successful candidate will lead the in vitro ADME and pharmacokinetic functions of the DMPK department at the Exton, PA site. The position involves overseeing a group of approximately 20 scientists performing studies to evaluate the pharmacokinetics, drug metabolism and drug-drug interaction potential of development and discovery-stage drugs.
The successful candidate will be responsible for setting performance and financial goals for the business unit and ensuring the required resources/personnel are in place to achieve the goals.
Roles & Responsibilities:
- Keep abreast of new scientific developments and regulatory requirements and ensure the work within the group is performed accordingly
- Have a general strategy of soliciting business, meet customers and provide scientific input so that the right studies are performed to address the scientific and/or regulatory question at hand
- Design studies as needed and include in study proposals /protocols
- Prepare study proposals at the request of customers
- Provide guidance in the preparation of study protocols for in vitro and in vivo studies
- Help with the interpretation of data and conclusions/summaries for completed studies
- Ensure that all studies are conducted efficiently and in a timely manner while maintaining highest quality of data
- Ensure that the scientists follow Frontage SOPs, DMPK guidelines, and study protocols while conducting studies
- Other duties as assigned
Education, Experience & Skills Required:
- PhD in chemistry, biology, or related area
- More than 10 years of related experience in the biotech, pharma or preclinical CRO industry
- Solid knowledge of in vitro DMPK, drug transporters, enzyme kinetics and pharmacokinetics
- Familiarity with bioanalysis using LC/MS/MS
- Experience with drug discovery and development and the toxicology, drug metabolism, and pharmacokinetics data required at various stages of the drug discovery and development process
- Good track record in leading small to large DMPK groups
Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.
Skills Required
- PhD in chemistry, biology, or related area
- More than 10 years of related experience in the biotech, pharma or preclinical CRO industry
- Solid knowledge of in vitro DMPK, drug transporters, enzyme kinetics and pharmacokinetics
- Familiarity with bioanalysis using LC/MS/MS
- Experience with drug discovery and development processes
- Good track record in leading DMPK groups
What We Do
Frontage Laboratories, Inc. is a CRO that provides integrated, science-driven, product development services throughout the drug discovery and development process to enable pharmaceutical and biotechnology companies to achieve their development goals. Comprehensive services include drug metabolism and pharmacokinetics, analytical testing and formulation development, preclinical and clinical trial material manufacturing, bioanalysis, preclinical safety and toxicology assessment and early phase clinical studies. Frontage has enabled many biotechnology companies and leading pharmaceutical companies of varying sizes to advance a myriad of molecules through development and file regulatory submissions in the United States, China and other countries.
