Engineer - Project Manager, Continuous Improvement & Portfolio Change Management

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Indianapolis, IN, USA
In-Office
65K-167K Annually
Healthtech • Biotech • Pharmaceutical
The Role

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Position Overview

The Project Manager, Portfolio Level Continuous Improvement & Change Management, will be a critical member of the Capital Portfolio Operations team, driving strategic initiatives that enable GFD’s ambitious $10–12B annual capital agenda across eight mega programs. Reporting directly to the Portfolio Governance & Integration Director, this role will serve as a linchpin for continuous improvement, organizational change, and cross-program alignment—ensuring GFD operates as a united, high-performing capital delivery engine.

Key Responsibilities
  • Continuous Improvement Leadership: Design, implement, and operationalize systematic lessons learned processes across the capital portfolio. Capture feedback and insights, structure and analyze root causes, and translate findings into actionable improvements for program management and project execution.
  • After Action Reviews: Facilitate after action reviews across all major capital projects and programs. Engage program teams and leadership to ensure transparent dialogue and effective documentation of performance, outcomes, and improvement opportunities.
  • Root Cause Analysis: Lead root cause investigations for portfolio-level and program-specific issues. Collaborate with engineering, finance, and procurement teams to identify systemic challenges and develop robust solutions that enhance capital delivery, cost controls, and risk mitigation.
  • Change Management: Own organizational change management strategies that support cross-program governance, process standardization, and adoption of new tools or frameworks. Serve as a change champion by aligning stakeholders, facilitating communication, and embedding best practices across GFD’s capital programs.
  • Portfolio Integration: Partner with Program Directors and other functional leads to ensure continuous improvement initiatives are integrated into portfolio operating rhythms and decision forums.
  • Reporting & Communication: Develop and manage consistent messaging and reporting on continuous improvement activities, outcomes, and change adoption. Support the Portfolio-Level Communications Manager in driving updates to executive leadership and broader GFD teams.
  • Mentorship & Development: Support the growth and onboarding of project management talent by sharing lessons learned, proven methodologies, and best practices in project delivery and change management.
Required Qualifications
  • Bachelor’s degree (or higher) in Engineering (Chemical, Mechanical, Electrical, or Civil) or related discipline.
  • Minimum 5 years of experience in project management within pharmaceutical manufacturing, capital projects, or related industry.
  • Experience in continuous improvement, including experience leading after action reviews and root cause analysis.
  • Experience with organizational change management principles and practical application within large, matrixed environments.
  • Experience managing cross-functional teams and driving collaboration among diverse stakeholders.
  • Experience developing and implementing process improvement frameworks at portfolio and program levels.
Preferred Skills
  • Lean Six Sigma, CIC, or similar process improvement certification.
  • Experience with dashboard/reporting integration for capital project portfolios.
  • Proficiency in Power BI, Oracle Unifier Accelerator, Bluebeam and Visio
  • Project Management Professional (PMP) or equivalent certification.
  • Familiarity with pharmaceutical manufacturing standards and regulatory environments.
  • Excellent communication, facilitation, and analytical skills.
Additional Information
  • Domestic and International Travel required (~20%)
  • Work will be conducted in a variety of environments (office, manufacturing, and construction sites)

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.


Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$64,500 - $167,200

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly

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The Company
HQ: Indianapolis, IN
39,451 Employees
Year Founded: 1876

What We Do

Eli Lilly and Company engages in the discovery, development, manufacture, and sale of products in pharmaceutical products business segment. For more than a century, we have stayed true to a core set of values – excellence, integrity, and respect for people – that guide us in all we do: discovering medicines that meet real needs, improving the understanding and management of disease, and giving back to communities through philanthropy and volunteerism.

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