About Us…
Obsidian Therapeutics is pioneering engineered cell and gene therapies to deliver transformative outcomes for patients. Obsidian’s programs apply our cytoDRiVE® technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety. Obsidian’s lead program is currently in clinical development for the treatment of patients with metastatic melanoma and non-small cell lung cancer.
We’re proud of our diverse talented team and committed to cultivating an environment of inclusion where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. Our Research team is based in the heart of Cambridge, MA, and Technical Operations team is based in our purpose built facility in Bedford, MA. Obsidianites enjoy a highly collaborative culture, competitive salary and benefits, and potential for ownership through stock options.
Our Opportunity...
We are looking for a highly motivated Director/Senior Director, G&A IT Digital Business Partner with a strong background in enterprise business systems, finance systems ownership and public-company SOX ITGC execution.
This is a business-facing, hands-on individual contributor role responsible for partnering with Finance, People, Legal, and Procurement to shape and deliver the roadmap, operations, integrations, compliance, and continuous improvement of Obsidian's core G&A systems portfolio, . You will help ensure platforms such as NetSuite, Adaptive, FloQast, ADP, Greenhouse, Pave, Concur, Prendio, ContractLogix, and ActiveDisclosure/DFIN remain scalable, secure, compliant, and aligned with business needs, while managing key vendor relationships and building the data, process, and integration foundations for a future ERP transformation.
As a member of our Digital Solutions & Technology team, you will be a vital part of a highly collaborative group working to unlock the promise of precision cell therapy for patients, starting with our lead program amsoki-cel (OBX-115), a novel engineered tumor-infiltrating lymphocyte (TIL) cell therapy that uses our proprietary cytoDRiVE® platform. This is a unique opportunity to be a valuable contributor in a well-funded clinical company with field-leading advisors, best-in-class partners, and an experienced team.
This is a Hybrid role based out of our Cambridge, MA location until Q2, 2027 when our Bedford, MA office space expands to become our single MA location.
You Will...
Core responsibilities
- Partner with business leaders to define and deliver scalable, compliant solutions that support corporate growth, financial reporting, and operational effectiveness.
- Own the G&A technology portfolio supporting Finance, People, Legal, Procurement, Investor Relations, external reporting, and related corporate functions.
- Serve as the Digital owner for NetSuite and associated platforms, including Adaptive, FloQast, Concur, Prendio, ActiveDisclosure/DFIN, ADP, and related integrations.
- Responsible for roadmap, delivery, and operational performance of G&A business systems and associated vendors.
- Ensure SOX ITGC compliance for assigned systems, including access management, change management, operational controls, audit support, and remediation activities.
- Govern integrations, master data, reporting dependencies, and role-based access across the G&A application landscape.
- Drive automation, AI adoption, process simplification, and continuous improvement while safeguarding company data and regulated processes.
- Partner with Information Security, Internal Audit, Finance, and business stakeholders to ensure cybersecurity, privacy, SOX, and regulatory requirements are met.
You Bring...
Core Qualifications
- Bachelor's degree in information systems, Business, Finance or a related field, with 12+ years (15+ Senior Director) in IT business systems, enterprise applications or finance systems.
- Public-company experience with direct, hands-on ownership of SOX ITGCs — access reviews, change mgmt, segregation of duties, audit evidence, vendor assurance and remediation — not just audit participation.
- Experience supporting Finance and HR systems in a regulated, audit-driven environment; biotech, pharma, medtech or life sciences are strongly preferred.
- Hands-on NetSuite or comparable ERP experience, with enough finance process fluency to be credible with Accounting, FP&A, Procurement, Payroll, Legal and external reporting.
- Track record managing SaaS business systems end to end: vendor releases, integrations, UAT, data flows, role-based access and audit-ready documentation.
- Strong business partner with sound judgment and plain-language communication; builds trust across Finance, People, Legal, Procurement and the executive team while holding control discipline.
- Cultivates collaboration, transparency, and accountability within and across teams; recognizes success requires interdisciplinary thinking and partnership.
- Inspires confidence, credibility, and trust internally and externally; recognized for high integrity.
- Operates with Urgency, adept at building buy-in and driving alignment within and across teams, senior leadership, and external partners.
- Exceptional communication skills in verbal, written, and visual formats, and adapted to the audience.
- Tenacious and resilient – has navigated significant challenges (scientific and business) and is not easily daunted.
- Excellent organizational skills; able to manage multiple tasks of varying degrees of complexity in parallel.
- Remains calm under pressure and leads others through complex situations.
- Seeks the data, information, and support needed (internally and externally) to make efficient and informed decisions and meet objectives.
- Builds followership by being transparent, persuasive, excited about the work, and willing to work hard together to get the job done.
- Continuous learner – actively follows innovations in area of expertise, fosters innovative thinking, and adopts novel approaches that are fit for purpose.
- Reflective and self-aware; leads by example with a growth mindset.
Bonus Qualifications
- SAP exposure or implementation experience, particularly a migration from NetSuite or another mid-market ERP to SAP.
- Clinical-stage or early commercial public company biotech or pharma experience.
- SEC reporting tools, investor portals, controlled disclosure workflows, or external financial reporting support.
- Familiarity with GxP, 21 CFR Part 11, CSV/CSA, or the overlap between financial controls and validated/regulatory systems.
Obsidian is committed to equitable and transparent pay practices.
The anticipated base salary range for this role is below. The actual base salary offered will be determined based on a combination of factors, including applicable qualifications, level of education, the depth of experience, unique skills, geographic location, internal equity, and/or business needs. The actual base salary offered will be in accordance with federal, state, and/or local wage requirements for the role’s location.
Our competitive compensation package includes an annual incentive bonus as a percentage of actual base salary and long-term incentives in the form of employee stock options, both of which are commensurate with the role’s level. We also offer a generous benefits package which includes comprehensive medical, dental, and vision coverage; company contributions to health savings and retirement accounts; ample paid time off; access to wellness programs; and rich career growth opportunities.
Obsidian is proud to be an equal opportunity employer, cultivating a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics.
Skills Required
- Bachelor’s degree in information systems, Business, Finance, or a related field
- 12+ years of experience in IT business systems, enterprise applications, or finance systems; 15+ years for Senior Director level
- Public-company experience with direct, hands-on ownership of SOX ITGCs, including access reviews, change management, segregation of duties, audit evidence, vendor assurance, and remediation
- Experience supporting Finance and HR systems in a regulated, audit-driven environment
- Hands-on NetSuite or comparable ERP experience with finance process fluency
- Experience managing SaaS business systems end to end, including vendor releases, integrations, UAT, data flows, role-based access, and audit-ready documentation
- Strong business partnering, communication, judgment, organizational, collaboration, and stakeholder management skills
- SAP exposure or implementation experience, particularly migration from NetSuite or another mid-market ERP to SAP
- Clinical-stage or early commercial public-company biotech or pharma experience
- Experience with SEC reporting tools, investor portals, controlled disclosure workflows, or external financial reporting support
- Familiarity with GxP, 21 CFR Part 11, CSV/CSA, or financial controls within validated and regulated systems
What We Do
Obsidian Therapeutics is pioneering controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases. Obsidian’s programs apply our cytoDriveTM technology in cell and gene therapy products to control expression of proteins for enhanced therapeutic efficacy, including our lead program cytoTIL15 engineered to make TILs more effective for more patients. Our aspirations are high, and we’re built to deliver – well-funded with blue chip investors, engaged field-leading advisors, strong partnerships with industry leaders, and a highly experienced, dynamic, innovative and collaborative team, collectively focused on delivering transformative therapies in areas of greatest clinical need. Located in the heart of Cambridge with a new laboratory facility in Bedford, we’re proud of our diverse talented team and committed to cultivating an environment of inclusion where we strive to instill a strong sense of belonging, and support each Obsidianite to continuously learn and contribute their best work. We offer competitive salary and benefits, and potential for employee ownership through stock options
