Position Summary:
Praxis is hiring a Director, Quantitative Lead to guide the statistical design, quantitative decision-making, and modeling across our clinical development programs. This senior role blends biostatistics, exposure-efficacy/safety modeling, exploratory analyses and quantitative strategy within a modern, metadata-driven analytical environment.
You'll partner closely with Statistical Data Scientists, Statistical Programmers, Clinical Development, and Clinical Pharmacology to ensure that all quantitative outputs from exploratory modeling to SAP-driven analyses are scientifically rigorous, reproducible, and aligned with program objectives. This is both a strategic and hands-on scientific role, ideal for a senior quantitative leader who enjoys both methodology and applied modeling.
Primary Responsibilities:
- Lead statistical design for clinical studies, including estimands, endpoint selection, sample size, and modeling approaches
- Author or oversee SAPs and associated analysis specifications
- Guide quantitative strategy across exploratory, interim, and confirmatory study phases
- Lead exposure-efficacy and exposure-safety analyses using clinical exposure metrics
- Apply statistical modeling approaches in R or Python
- Develop simulation-based scenarios to support dose selection and benefit-risk assessments
- Oversee blinded exploratory analyses using ARR and other metadata-driven layers
- Guide Statistical Data Scientists in the implementation, visualization, and reproducible execution of exploratory models
- Ensure quantitative analyses are implemented within reproducible, metadata-driven frameworks
- Partner with Statistical Data Scientists and programming teams to translate quantitative intent into executable specifications
- Support validation, traceability, and audit readiness of all quantitative workflows
- Provide quantitative interpretation for study teams, governance discussions, and regulatory documents
- Review CSRs and contribute to regulatory responses involving quantitative rationale
- Mentor Statistical Data Scientists and Statistical Programmers on modeling, statistical methodology and interpretation.
Qualifications and Key Success Factors:
- PhD or Master’s in Biostatistics, Statistics, Data Science, Applied Mathematics, or related quantitative discipline
- 8-12+ years of quantitative experience in clinical development
- Statistical modeling (MMRM, GLM, logistic models, Bayesian methods, longitudinal models)
- Exposure-efficacy and/or exposure-safety analyses
- SAP authorship and study design
- Simulation-based decision support
- Strong proficiency in R (required); Python or Stan experience a plus
- Familiarity with CDISC ADaM/SDTM preferred
- Excellent communication skills with the ability to present quantitative insights to cross-functional stakeholders
- Experience working closely with Statistical Data Scientists and Statistical Programmers.
Compensation & Benefits
At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive. This includes 99% of the premium paid for medical, dental and vision plans. We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future? We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP.
We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns. Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring. We aim high, collaborate hard, and produce results. Let’s achieve the impossible together!
To round out our world-class total rewards package, we provide annualized base salary compensation in the range listed below. Final salary range may be modified commensurate with job level, education, and experience.
Company Overview
Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.
Diversity, Equity & Inclusion
Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.
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Top Skills
What We Do
Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. Praxis is applying insights into the genetic mutations that drive excitation-inhibition imbalance in diseases to select biological targets for rare and more prevalent neurological disorders.
We share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders.
Praxis is applying genetic insights to the discovery and development of therapies for rare and more prevalent neurological disorders through our proprietary small molecule platform, Cerebrum™, and antisense oligonucleotide (ASO) platform, Solidus™, using our understanding of shared biological targets and circuits in the brain.
