Company Overview
Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugate therapies. Our pipeline includes varegacestat, a late-clinical stage GSI; IM-1021, a clinical-stage ROR1 ADC; and IM-3050, a FAP-targeted radiotherapy that recently received IND clearance. We are also advancing a broad portfolio of early stage ADCs pursuing undisclosed solid tumor targets.
Position Overview
Immunome is hiring a Director, IT Planning and Program Management to help build and lead our internal IT Project Management Office (IT PMO) from the ground up. This role will establish portfolio governance and decision-making practices, standardize project delivery, and improve transparency and predictability across IT and technology-enabled initiatives. The Director will partner closely with IT and business leaders across Research, Tech Ops, Development, Commercial, and G&A functions to drive predictable delivery of infrastructure and enterprise system implementations that enable scale, portfolio advancement, and commercial readiness in a regulated life sciences environment.
Responsibilities
Establish and Lead the IT PMO Operating Model
- Build Immunome’s enterprise IT PMO from the ground up, including the operating rhythm, standards, templates, and portfolio performance metrics.
- Define how projects are governed and delivered (IT-led, business-led, and vendor-led) and set clear roles and expectations for project managers and functional project leads.
- Own IT portfolio financial management (business cases, forecasting, vendor spend tracking, planning and budgeting, and reporting of spend vs actuals) in partnership with IT leadership and Finance.
- Provide leadership and oversight of the IT PMO team, including internal project managers and external contractors/consulting partners, scaling the team structure, capabilities, and capacity in alignment with company growth and portfolio demand.
Portfolio Intake, Prioritization, and Capacity-Based Planning
- Implement end-to-end demand intake and portfolio planning, including intake criteria, business case expectations, prioritization methods, and sequencing.
- Maintain portfolio roadmaps and dependency management, and partner with IT and business leaders to align priorities to capacity, funding, and critical milestones using scenario-based planning across internal teams and external partners.
Governance, Decision Support, and Executive Visibility
- Establish governance processes that enable timely decisions for technology investment, system selection, and program execution (including escalation paths and decision-ready materials).
- Support and help run the IT Steering Committee (ITSC) under the direction of the committee Chair; provide regular IT portfolio updates to committee members.
- Drive transparent reporting on schedule, risks/issues, dependencies, and delivery health across the portfolio.
- Define portfolio success measures including adoption, operational readiness, and value realization, and lead post implementation reviews to improve delivery performance and business outcomes.
Program Execution Excellence
- Drive consistent project controls across the portfolio (scope, schedule, change control, stakeholder communications) and coach project managers/project leads.
- Provide delivery governance for vendor-led initiatives, ensuring accountability to plans, milestones, acceptance criteria, and risk management.
Regulated, Audit-Ready Delivery and PMO Enablement
- Develop and maintain IT PMO policies, procedures, and SOPs aligned with FDA/GxP expectations; ensure project delivery practices support regulated system implementation and validation/assurance.
- Advise on IT PMO tooling and workflows (e.g., Smartsheet, ServiceNow, Box GxP/SharePoint) and drive adoption through training and change management.
Qualifications
- Bachelor’s degree required; advanced degree preferred.
- A minimum of 10+ years of progressive experience in IT project/program/portfolio management and/or PMO leadership; life sciences/biotech experience strongly preferred.
- Demonstrated experience designing, implementing, and scaling PMO frameworks in growing or transforming organizations.
- Demonstrated experience leading complex enterprise system and infrastructure implementations in a high growth life sciences organization across R&D and G&A functions.
- PMP certification and ITIL v4 certification or equivalent credentials are a plus.
Knowledge and Skills
- Strong command of project, program, and portfolio management methodologies; experience establishing governance models and executive-level reporting.
- Working knowledge of regulated environments and enterprise controls, including relevant concepts such as SOX, privacy (e.g., GDPR), and FDA 21 CFR Part 11.
- Experience supporting validation/assurance approaches (CSV/CSA) and third-party risk management (TPRM) in GxP-regulated environments.
- Strong financial and analytical skills, able to build business cases, forecast and track spend, and translate portfolio data into decision ready insights for executives.
- Proficiency with PMO tools used for portfolio planning, reporting, and governance (e.g., Smartsheet, ServiceNow, Box GxP/SharePoint, Teams/Zoom).
- Proven ability to create policies, SOPs, and training programs that drive adoption and consistent execution.
- Excellent stakeholder management, communication, and influence skills; ability to lead through ambiguity and align cross-functional teams.
- High integrity and sound judgment when handling sensitive systems, data, and business-critical initiatives.
E/E/O
Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
E-Verify
Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish).
Top Skills
What We Do
Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs). Our most advanced pipeline programs are varegacestat (formerly AL102), a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors; IM-1021, a ROR1-targeted ADC which is currently in a Phase 1 trial; and IM-3050, a FAP-targeted radioligand, which recently received IND clearance. Our pipeline also includes IM-1617, IM-1335, and IM-1340, all of which are preclinical ADCs pursuing undisclosed targets with expression in multiple solid tumors.
