Control Systems and Infrastructure Support Lead (ITOT Mgmt.)
The Opportunity
Are you passionate about Information (IT) and Automation Technology (OT) and aspiring to make a meaningful impact? Are you curious to shape a digital manufacturing architecture, ready to advance competitiveness on the market?
We Make Medicines!
Behind every product sold by Roche is Pharma Global Technical Operations
(PT). Starting with Phase I of the development process and continuing through to product maturity, PT makes lifesaving medicines at 11 locations, with the support of partners from around the world. Information (IT) and Automation
Technology (OT) teams are key in producing and delivering medicine to patients. The organization is currently undergoing a transformation towards digitalization, advancing fundamental elements to meet future needs, such as using new technologies.
This position, based in Genentech's South San Francisco, California facility, provides the opportunity to have a key role in a highly automated pharmaceutical drug substance and drug product manufacturing facilities. The site employs highly integrated computer control systems to manage plant operations and
manufacturing data. This role will report to the IT OT Head at the site.
What you will be working on:
Provide people leadership and development for a team of site systems engineers and system owners.
Maintain the Control Systems strategy and roadmap in collaboration with business partners, IT counterparts, and external vendors.
Maintain accountability for the execution of the Site Control Systems roadmap and contribute to the overarching Site Digital strategy.
Oversee 24/7 technical support for Manufacturing Computerized Systems (GMP and non-GMP) within a high-stakes manufacturing environment.
Proactively manage and mitigate dependencies as global and local systems evolve, including upgrades (e.g. MQTT, Containerization) and new technology implementations.
Act as the primary technical advisor, fostering seamless collaboration between site operations and IT teams.
Drive the reliability, continuous improvement, and lifecycle management of site control systems.
Supervise engineering tasks and oversee critical application administration, including patching, upgrades, audit support, performance tuning, and system log maintenance.
Contribute to the design and development of scalable control system architectures that align with business requirements.
Execute rigorous computer system validation and maintain compliance across the control system lifecycle.
Support Cybersecurity initiatives for Manufacturingq.
Negotiate and Maintain support/service agreements with key vendors.
Support OPEX/CAPEX financial planning activities at the site.
Participate in monthly meetings focused on OT Cybersecurity to ensure alignment at the global level.
Support the end-to-end Biologics Value Chain, spanning from Clinical (CSC, PTDN) Drug Substance and Drug Product operations.
Provide support for key stakeholder functions including Pilot Plant Automation and Clinical Packaging.
Represent ITOT as a member of Leadership Teams within the business.
Serve as a member of the Site ITOT Leadership Team.
Who You Are
Bachelor’s degree in Engineering, Computer Science, IT or related engineering or scientific discipline.
A minimum of 10 years systems engineer experience involved in the design, implementation, and/or support of control systems, preferably in a regulated industry is preferred.
24X7 support, participate in an on-call environment to meet business continuity requirements, including weekends and holidays as required.
Experience with control system hardware e.g., controller, power supplies, and I/O’s.
Experience with Emerson DCS DeltaV, MES Syncade, OSIsoft PI, Rockwell Automation AssetCentre, iFIX, FactoryTalk, Studio 5000 Logix, and various OPC architectures is a plus.
Experience working with Antivirus and backup applications for Control Systems.
Understanding of the Purdue Model, Network Segmentation and OT Cybersecurity is a plus.
The expected salary range for this position based on the primary location of South San Francisco, CA is $150,200 - $279,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Relocation benefits are not available for this job posting.
#RDT2026
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Skills Required
- Bachelor's degree in Engineering, Computer Science, IT, or a related engineering or scientific discipline
- At least 10 years of systems engineering experience involving the design, implementation, and/or support of control systems
- Availability to participate in 24/7 on-call support, including weekends and holidays as required
- Experience with control system hardware, including controllers, power supplies, and I/O systems
- Experience with Emerson DCS DeltaV, MES Syncade, OSIsoft PI, Rockwell Automation AssetCentre, iFIX, FactoryTalk, Studio 5000 Logix, or OPC architectures
- Experience with antivirus and backup applications for control systems
- Understanding of the Purdue Model, network segmentation, and OT cybersecurity
Genentech Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Genentech and has not been reviewed or approved by Genentech.
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Healthcare Strength — Health coverage is described as comprehensive across medical, dental, vision, mental health, and prescriptions, supported by HSAs/FSAs and broad wellness resources. On‑site fitness and health centers, mental‑health clinicians, and specialized programs like fully covered preventive cancer screenings and menopause support deepen the offering.
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Retirement Support — Retirement benefits feature a 401(k) with up to a 4% company match plus an additional annual 6% company contribution to eligible pay. Additional financial protections such as life and accident insurance complement salary, bonuses, and stock options.
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Leave & Time Off Breadth — Time away includes about 20 paid vacation days, paid holidays, personal days, and a year‑end shutdown. A paid six‑week sabbatical every six years notably expands long‑term time‑off flexibility.
Genentech Insights
What We Do
Considered the founder of the industry, Genentech, now a member of the Roche Group, has been delivering on the promise of biotechnology for more than 40 years. Genentech is a biotechnology company dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. We're passionate about finding solutions for people facing the world's most difficult-to-treat conditions. That is why we use cutting-edge science to create and deliver innovative medicines around the globe. To us, science is personal. Making a difference in the lives of millions starts when you make a change in yours.
