Why Genentech
Join us during our fiftieth year—a landmark of "entrepreneurial grit and discovery." Here, your leadership will directly shape our ability to deliver life-changing foundational therapies while advancing your own career in a supportive, growth-oriented environment.
Open Up Your World. From Day One.
We continue to evolve the engine that makes our mission possible, and we are looking for a senior strategic partner to serve as the Chief of Staff & Head of Operations and Administration for the Ophthalmology Squad and Network for USCMG. This is not just an operations leadership role; it is a critical leadership opportunity to shape a highly volatile, fiercely competitive therapeutic area during a period of unprecedented growth and possibility while pioneering Genentech’s Commercial Portfolio Organization "Velocity with Purpose" strategy
The Opportunity
As the Chief of Staff & Head of Operations and Administration, you will serve as a form of high impact internal management consultant, trusted advisor, and "capacity multiplier" for the Ophthalmology Squad Leader, Squad, and Network. You will navigate a profound clinical, macroeconomic, and operational evolution in the retinal disease landscape, standing at the forefront of the fight against vision loss.
You will lead the "US Ophthalmology Center Square"—the operational nerve center of the therapeutic area—seamlessly blending three distinct strategic, operational, and delivery pillars: serving as the Head of Operations, managing a dedicated team of administrative professionals and Operations Managers, and acting as the primary conduit for cross-functional communications and strategy across the Ophthalmology ecosystem.
Key Responsibilities
Strategic Advisory & Management Consulting:
Act as a confidential sounding board and thought partner to the Squad Leader, deploying advanced frameworks (Value-Based Pricing, McKinsey 7S, Kotter's Change Model) to navigate extreme market volatility, pricing pressures, and biosimilar deflation.
Synthesize clinical efficacy data with health economic outcomes, mapping the patient journey to identify friction points and optimize commercial positioning against emerging competitive threats.
Operational Excellence & The "Ophtha Center Square":
Manage the design and delivery of the Ophthalmology Therapeutic Area Operating Rhythm (Goals, Objectives, Leading Indicator KPI, Budgets and Operational Expense and Resource Management) with Finance and other stakeholders
Orchestrate the operational deployment of complex, large-scale initiatives, including the rollout of continuous-delivery ocular implants (e.g., Susvimo) and the systemic shift toward Office-Based Surgery (OBS) centers.
Utilize Supply Chain Operations Reference (SCOR) models to benchmark and optimize logistics for surgical implants and future cell therapy launches.
Team Leadership & VACC Capability Building:
Lead, mentor, and grow a team of Operations Managers and Administrative professionals, driving a rigorous delegation process that handles operational "plumbing" so you can focus on high-value strategic synthesis.
Embody the VACC leadership framework (Visionary, Architect, Coach, Catalyst) to remove operational bottlenecks, decentralize decision-making, and foster a psychologically safe, high-performing culture.
Cross-Functional Leadership & Narrative Stewardship:
Act as the critical bridge connecting the Ophthalmology Squad with the broader Genentech matrix (gRED, Pharma Technical Operations, Global Medical Affairs), ensuring uniform alignment with our 2026 "Velocity with Purpose" mandate.
Orchestrate the narrative for the Squad Leader, drafting strategic communications that inspire internal networks and external stakeholders while accelerating our transition to an agile, "System 1.0" operational model.
Who You Are:
10+ years experience in operations, communications, or marketing within the pharmaceutical or biotech industry and a bachelor's degree
Operational discipline and strategic field or customer insight. Extensive project management expertise, including leading complex, cross-functional initiatives in a global matrix environment
Proven ability to apply sophisticated management consulting frameworks (HTA, VoC, Change Management) to solve complex biopharmaceutical challenges
Proven experience as a strategic thought partner to senior leaders, with a track record of driving change in complex environments
Commitment to compliance with all corporate policies and guidelines
Location
This role is located in South San Francisco and offers a hybrid schedule working 3 days per week on campus
No relocation benefits are available for this posting
The expected salary range for this position based on the primary location in California is $166,500 - $309,100. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Genentech Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Genentech and has not been reviewed or approved by Genentech.
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Healthcare Strength — Health coverage is described as comprehensive across medical, dental, vision, mental health, and prescriptions, supported by HSAs/FSAs and broad wellness resources. On‑site fitness and health centers, mental‑health clinicians, and specialized programs like fully covered preventive cancer screenings and menopause support deepen the offering.
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Retirement Support — Retirement benefits feature a 401(k) with up to a 4% company match plus an additional annual 6% company contribution to eligible pay. Additional financial protections such as life and accident insurance complement salary, bonuses, and stock options.
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Leave & Time Off Breadth — Time away includes about 20 paid vacation days, paid holidays, personal days, and a year‑end shutdown. A paid six‑week sabbatical every six years notably expands long‑term time‑off flexibility.
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What We Do
Considered the founder of the industry, Genentech, now a member of the Roche Group, has been delivering on the promise of biotechnology for more than 40 years. Genentech is a biotechnology company dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. We're passionate about finding solutions for people facing the world's most difficult-to-treat conditions. That is why we use cutting-edge science to create and deliver innovative medicines around the globe. To us, science is personal. Making a difference in the lives of millions starts when you make a change in yours.
