Associate Scientist, Platform Technology

Posted 2 Days Ago
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Cambridge, MA
Senior level
Biotech
The Role
The Associate Scientist will contribute by leading guide design, executing high-throughput CRISPR screens, analyzing data, and ensuring quality control of screening processes using various CRISPR delivery systems. Responsibilities include document results in electronic laboratory notebooks and assist with RNP complexation.
Summary Generated by Built In

Description

At Editas Medicine, we are pioneering the possible. Our mission and commitment is to translate the power and potential of the CRISPR/Cas12a and CRISPR/Cas9 genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases.

Why Choose Editas?

At Editas Medicine, we’re a team of courageous problem solvers, harnessing the power and potential of CRISPR gene editing to transform the future of medicine. Driven by a shared purpose to serve people living with serious diseases, we succeed together through collaboration, mutual respect, and innovation. If you want to be part of a team where your voice is heard and respected, where you can operate at the forefront of gene editing, and push the boundaries of what’s possible in medicine, come join us and become an Editor!

Decoding The Role:

As an Associate Scientist, Platform Technology, you’ll be a vital contributor to our mission and our success. In this role, you will use various CRISPR delivery systems to execute high-throughput screens, and extract samples for NGS (DNA), RT-ddPCR (RNA) and protein (flow or Western blots/Jess automated blots) readouts to identify lead guides across our internal and external programs. You will track screens through the LIMs and document in your ELN and be responsible for the analysis and summary of the screens to inform follow-up experiments. An ideal candidate should have a strong background in immortalized (hepatocytes) and primary cell culture (HSC, T cells) and have experience screening in these cell types using various CRISPR delivery systems, including RNPs and LNPs.

Characterizing Your Impact:

As the Associate Scientist, Platform Technology, you will:

  • As the Associate Scientist I, Platform Technology, you will be responsible for:
  • Lead guide design, screening and selection of lead guide using editing and/or function assays for internal and external partner programs.
  • Analyze and summarize screening results into proper documentation (ELN, Study Reports) 
  • Implementation of a high-through LNP screening workflow, including automated LNP-formulations 
  • Assist with RNP complexation and perform QC for internal program use 
Requirements

The Ideal Transcript:

To thrive in this role, you’ll need:

  • B.S. in cell biology, or related field with 5+ years of relevant experience in industry; or M.S. in cell or molecular biology with 2+ years of relevant experience in industry 
  • Independently design and run screening experiments, extract gDNA, submit for sequencing, analyze, and present data 
  • Experience with mammalian cell culture, including immortalized and primary cells (ex. Liver Cells and HSCs) 
  • Proficient in executing and analyzing functional assays including flow cytometry and western blots 
  • Experience working with different screening modalities such as guide RNAs and LNPs and knowing how to formulate both RNP and LNPs 
  • Experience with data analysis software such as PRISM, Tableau, and FlowJo
  • Familiar in molecular biology analyses such as qPCR and ddPCR 
  • Familiar working with lab automation including both liquid handling robots (Biomek I7s, Mantis, Echo) and plate readers (Envision) 
  • Excellent communication and interpersonal skills fostering effective teamwork 
Benefits

Benefits Summary:

Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.

Aspire to be an Editor? We invite you to apply and join us at the forefront of innovation and be a key contributor to realizing Editas Medicine's mission of developing transformative medicines for people living with serious diseases..

Top Skills

Python
R
The Company
HQ: Cambridge, MA
268 Employees
On-site Workplace
Year Founded: 2013

What We Do

What if you could repair broken genes? That is the question we ask ourselves every day at Editas Medicine. We’re a leading genome editing company focused on translating the power and promise of our proprietary genome editing systems into medicines to help transform the lives of people with genetically-defined diseases. Our goal is to discover, develop, manufacture, and commercialize transformative medicines for a range of serious diseases, including eye diseases, blood diseases, and cancer.

We are a vibrant company full of hope, possibilities, and a belief that, working together as One Editas, we can truly revolutionize the development of medicines. We are on an important journey to unlock the full potential of genome editing technology. A journey fueled by our distinct culture, expert team of Editas Medicine ‘Editors’, and the patients we aspire to help around the world. Connect with us to hear about the tremendous progress and scientific advancements we’ve already made and the next breakthrough on the horizon. If you are ingenious, passionate and resilient, come join the revolution. Repairing broken genes is only the beginning.

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