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4DMT is a clinical-stage biotherapeutics company harnessing the power of directed evolution for targeted genetic medicines. We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products. We believe key features of our targeted and evolved vectors will help us create targeted product candidates with improved therapeutic profiles. These profiles will allow us to treat a broad range of large market diseases, unlike most current genetic medicines that generally focus on rare or small market diseases.
Company Differentiators:
• Fully integrated clinical-phase company with internal manufacturing
• Demonstrated ability to move rapidly from idea to IND
• Five candidate products in the clinic and two declared pre-clinical programs
• Robust technology and IP foundation, including our TVE and manufacturing platforms
• Initial product safety and efficacy data substantiates the value of our platforms
• Opportunities to expand to other indications and modalities within genetic medicine
GENERAL SUMMARY:
The Associate Scientist position in Biomarkers & Immunology will work with the lead Scientists for pathology sample processing, IHC/ISH assays, nucleic acid sample processing and ddPCR assays. The employee will be responsible for running experiments and sample processing to support method development and sample testing spanning vector characterization, non-clinical programs and to support clinical exploratory endpoints.
The Associate Scientist will be expected to work in a collaborative and flexible manner supporting other assays/workflows including biobank, safety and lab maintenance activities. In addition to hands on technical expertise, this position will be required to write up summaries/presentations of experimental data, maintain an up-to-date laboratory notebook and keep up with literature and scientific knowledge in the areas of gene therapy, histology techniques and bioanalytics.
KEY RESPONSIBLITIES
- Hands on execution/interpretation/reporting of IHC/ISH experiments
- Hands on method development/execution/interpretation/reporting of molecular biology (nucleic acid/ddPCR) experiments
- Hands on cross training/scientific support for other assays/workflows such as cell culturing and biobank activities
- Support Biomarker & Immunology department with sample processing and preparation
- Effective data summary and presentation to internal teams
- Histology imaging and sample archiving
- Lab support includes maintaining inventory and supply ordering and sample tracking of FFPE blocks and glass slides including shipping and receiving samples.
QUALIFICATIONS:
Education & Experience:
- BS or MS in related scientific discipline
- 2+ years industry experience
Skills:
- Histology/IHC/ISH method development and troubleshooting
- Histology sample processing
- Experience in molecular biology: qPCR, ddPCR
- Experience in accessioning/distribution of biosamples and maintaining biobank
- Experience in testing large sample sets in an organized and efficient manner
- Ability to adapt to changing priorities and requests
- Excellent communication skills with internal 4D colleagues and external audiences
- Excellent data summary/presentation skills
Additional requirements:
- 4-5 days/week onsite (as needed)
- Adhere to PPE requirements and complete all required safety training
- Adhere to 4DMT office and laboratory policies
Base salary compensation range: $118,000 - $136,000
Please note that salary will vary based on location, skill set, and a variety of other factors.
4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.
Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities
Top Skills
What We Do
4DMT is a clinical stage biopharma company inventing and developing innovative products to unlock the full potential of genetic medicine to treat large market and rare diseases. Our vector discovery platform Therapeutic Vector Evolution harnesses the power of directed evolution, a Nobel Prize-winning technology, with approximately one billion synthetic AAV capsid-derived sequences to invent customized and evolved vectors with improved therapeutic profiles compared to wild-type vectors. Our product design, development and manufacturing engine empowers us to efficiently create our valuable and diverse product pipeline. This combination of bold innovation and relentless execution gives 4DMT the capability to revolutionize genetic medicines and to strive for potential curative therapies. We have built a deep portfolio of genetic medicine product candidates, with five product candidates in clinical trials for seven patient populations.
We are taking genetic medicine to new heights and into new disease areas to overcome challenges not addressed by existing medicines. This incredible challenge drives our relentless and talented team. Our people are the essence of our inspiring, innovative and collaborative environment that encourages individual contributions and provides opportunities for career development. We seek the best in the industry who identify with our mission and our bold and innovative results-driven approach. Our 4 Guiding Principles drive the way we work together:
- Dare to Cure
- Break Boundaries
- Beyond Yourself
- Prepare & Executive Relentlessly
