Associate Scientist, Antibody Sciences

Position Overview

Immunome is seeking a highly motivated and detail-oriented Associate Scientist, Antibody Sciences to drive our in-house high-throughput (HTP) recombinant protein production efforts, spanning protein expression, purification, and characterization through basic screening in support of rapid, data-driven protein engineering and discovery workflows. 

This position will leverage analytical methods including SEC-UPLC, HIC-UPLC, DLS, reduced mass spectrometry, and biolayer interferometry (BLI) to characterize key properties of generated molecules and inform iterative protein engineering.  

A key function of this role will be overseeing the integrity and management of Immunome’s recombinant antibody and protein inventory, from intake through material distribution across the organization, enabling efficient iteration and seamless execution across the R&D team. 

Responsibilities

Research Design and Execution 

• Recombinant protein production, including high-throughput transient expression and purification. 

• Execute analytical assays including SEC-UPLC, HIC-UPLC, DLS, and reduced mass spectrometry. 

• Perform mammalian tissue culture in support of recombinant protein production. 

• Perform BLI-based assays, including single-point (yes/no) binding and full kinetic binding. 

• Maintain strong attention to detail and record keeping for inventory management of recombinant proteins. 

• Apply understanding of molecular biology and protein structure, including principles relevant to antibodies. 

Data Analysis and Interpretation 

• Analyze and summarize experimental data from protein production, characterization, and binding assays. 

• Interpret results and communicate implications to support iterative protein engineering and discovery workflows. 

Project Collaboration 

• Collaborate with colleagues across biology, chemistry, pharmacology, and translational medicine to achieve project goals. 

• Organize and share data to enable efficient collaboration with other research teams. 

Documentation and Reporting 

• Maintain detailed and accurate electronic laboratory notebooks documenting experimental procedures, results, and conclusions. 

• Prepare and present research findings to internal teams and contribute to project updates and strategic discussions. 

Continuous Learning and Development 

• Stay informed about the latest advancements in techniques for producing and characterizing protein therapeutics. 

• Proactively seek opportunities for professional development and contribute to the scientific growth of the research team. 

Qualifications

• Bachelor’s degree in molecular biology, biochemistry, biophysics, immunology, or related fields. 

• 3 years of lab experience in preclinical drug development in the biotechnology or pharmaceutical industry, or equivalent. 

• Strong understanding of molecular biology and protein sciences. 

• Experience with mammalian tissue culture. 

• Experience with Octet or similar instrument is a plus. 

• Experience with antibody discovery workflows is a plus. 

• Familiarity with Benchling is a plus. 

Knowledge and Skills

• Hands-on experience with recombinant protein expression and purification in high-throughput workflows. 

• Experience applying biophysical and analytical characterization methods (SEC-UPLC, HIC-UPLC, DLS, reduced mass spectrometry). 

• Working knowledge of BLI/Octet assay setup, execution, and data interpretation. 

• Strong laboratory skills in mammalian cell culture and sample handling for protein production. 

• Ability to analyze data, summarize results, and communicate findings to cross-functional teams. 

• Excellent documentation practices, including electronic laboratory notebooks and organized data management. 

• High attention to detail and strong organizational skills, including inventory management and sample tracking. 

• Ability to work effectively in a fast-paced, collaborative research environment and adapt to changing priorities.