At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
We are seeking a highly motivated and experienced Protein Engineer to join our BioTDR team at Eli Lilly and Company. This role will be responsible for the design, generation, optimization and novel delivery technologies of therapeutic antibodies to support our innovative drug discovery pipeline.
Job Responsibilities
Design and execute strategies for the generation and engineering of therapeutic antibodies using various technologies (e.g., rational design, phage display, yeast display) and molecular biology techniques.
Perform antibody humanization, affinity maturation, and developability optimization using rational design and high-throughput screening methods.
Support the development of antibodies for the delivery through genetic medicines.
Characterize antibody binding, specificity, and functional activity using biochemical and cell-based assays (e.g., ELISA, SPR, flow cytometry).
Collaborate closely with project teams, including discovery biologists, protein scientists, genetic medicine, in vivo pharmacologists, to advance therapeutic programs.
Analyze and interpret complex experimental data, present findings effectively, and contribute to scientific discussions and publications.
Maintain accurate and detailed experimental records and contribute to the development of intellectual property.
Stay current with scientific literature and new technologies in antibody engineering and drug discovery.
Basic Qualifications
Ph.D. in Molecular Biology, Immunology, Biochemistry, or a related field with 2+ years of relevant experience in protein engineering within an industry setting, or an M.S. with 5+ years of relevant experience.
Additional Skills and Preferences
Demonstrated expertise in protein design, generation, and engineering techniques, including molecular cloning, mutagenesis, and library construction.
Proficiency with various antibody display technologies (e.g., phage display, yeast display).
Strong hands-on experience with antibody characterization techniques (e.g., ELISA, SPR/BLI, flow cytometry).
Experience with viral delivery methods a plus.
Excellent analytical, problem-solving, and critical thinking skills.
Ability to work independently and collaboratively in a fast-paced, multidisciplinary environment.
Strong oral and written communication skills with the ability to effectively present scientific data.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is
$138,000 - $224,400Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
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Eli Lilly and Company engages in the discovery, development, manufacture, and sale of products in pharmaceutical products business segment. For more than a century, we have stayed true to a core set of values – excellence, integrity, and respect for people – that guide us in all we do: discovering medicines that meet real needs, improving the understanding and management of disease, and giving back to communities through philanthropy and volunteerism.
