2025 Summer Intern - Human Genetics

2025 Summer Intern - Human Genetics

Department Summary

The mission of Human Genetics within Genentech is to leverage public and internal genetic data to elucidate causal biological mechanisms driving human disease for purposes of drug discovery and development. This mission is supported by the research foci of the group, which range from computational methods development to targeted analyses of disease-relevant phenotypes. This year, we are searching for a motivated summer intern to improve variant effect and causal gene and cell type predictions from AI/ML models. 

This internship position is located in South San Francisco, on-site

The Opportunity

• Develop techniques for extracting biological signal from GWAS using ML models of regulatory sequence

• Contextualize and predict the impact of non-coding variation using ML models

• Train/finetune regulatory models on disease relevant genomics data (primarily single-cell ATAC-seq) 

• Participate in talks, journal clubs, and general research laboratory activities

• Ideally contribute to publication(s) resulting from your summer work

Program Highlights

•  Intensive 12-weeks, full-time (40 hours per week) paid internship.

• Program start dates are in May/June (Summer)

• A stipend, based on location, will be provided to help alleviate costs associated with the internship. 

• Ownership of challenging and impactful business-critical projects.

• Work with some of the most talented people in the biotechnology industry.

Who You Are (Required) 

Required Education:

• Must be pursuing a PhD (enrolled student).

Required Majors: Bioinformatics, Genomics, Genetics, Computational Biology, Machine Learning, Statistics, Computer Science

Required Skills: 

• Proficiency in Python and experience with frameworks for machine learning inference (e.g. pytorch, lightning)

• Working knowledge of techniques for statistical analysis (hypothesis testing, Bayesian inference etc)

• Familiarity with fundamental ML concepts and interpretation techniques such as transformers, saliency maps

• Knowledge of GWAS and related genetics-based analyses

Preferred Knowledge, Skills, and Qualifications

• Excellent communication, collaboration, and interpersonal skills.

• Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion.

Relocation benefits are not available for this job posting. 

The expected salary for this position based on the primary location of  California is $50 hour.  Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits.

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Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.