Top Tech Companies (2,090)
Oleander Medical Technologies is developing a revolutionary new treatment to destroy many of the most invasive.
Pronounced /ree-AH-tah/ Reata Pharmaceuticals, Inc. (Nasdaq:RETA) is a clinical-stage biopharmaceutical company that develops novel therapeutics for patients with serious or life-threatening diseases by targeting molecular pathways involved in the regulation of cellular metabolism and inflammation. Reata’s two most advanced clinical candidates, bardoxolone methyl and omaveloxolone, target the important transcription factor Nrf2 to restore mitochondrial function, reduce oxidative stress, and resolve inflammation.
JAAN Biotherapeutics is a private company that is developing novel therapies to activate the cardiac regeneration process in diseased hearts
AGTC is a clinical-stage biotechnology company that uses its proprietary gene therapy platform to develop products designed to transform the lives of patients with severe diseases, with an initial focus in ophthalmology. AGTC's lead product candidates are designed to treat inherited orphan diseases of the eye, caused by mutations in single genes that significantly affect visual function and currently lack effective medical treatments. AGTC's product pipeline includes six named ophthalmology development programs across five targets (X-linked retinoschisis (XLRS), X-linked retinitis pigmentosa (XLRP), achromatopsia, wet age-related macular degeneration and blue cone monochromacy), two non-ophthalmology programs (alpha-1 antitrypsin deficiency and adrenoleukodystrophy) and AGTC is continuing to develop early research studies in additional indications. The company is also exploring genetic defects in cells in the inner ear that lead to deafness and expects to advance several product candidates into development within the next few years. AGTC employs a highly targeted approach to selecting and designing its product candidates, choosing to develop therapies for indications having high unmet medical need, clinical feasibility and commercial potential. AGTC has a significant intellectual property portfolio and extensive expertise in the design of gene therapy products including capsids, promoters and expression cassettes, as well as, expertise in the formulation, manufacture and physical delivery of gene therapy products Find AGTC on YouTube at goo.gl/sMdJqX.
KaloCyte, Inc., a pre-clinical stage healthcare biotech startup company, located at the University of Maryland, Baltimore (UMB) as an Affiliate of the UM BioPark. KaloCyte’s offices and labs are sited within the UM School of Medicine’s Center for Blood Oxygen Transport and Hemostasis (CBOTH) directed by Allan Doctor, MD (KaloCyte Co-Founder and CSO). KaloCyte was founded in 2016 by a distinguished team of Washington University in St. Louis researchers in physiology, bioengineering, and trauma care, with support from the BioGenerator Fundamentals program. KaloCyte has demonstrated proof of concept for ErythroMer, a dried, bio-inspired artificial red blood cell envisioned for use when stored red blood cells are unavailable, undesirable or in short supply. KaloCyte is supported by $7.5M in federal awards and $2.5M investor funding. ErythroMer is a first-in-class, bio-inspired nanoparticle-encapsulated human hemoglobin, which mimics the vital oxygen-carrying functionality of RBCs and can be freeze-dried for long-term storage. Erythromer’s synthetic outer membrane, donut-shape and surface area allow for physiologically realistic gas exchange. The synthetic polymer shell is “immune-silent”, inert and carries no blood antigens, eliminating the need to type and cross-match as with stored blood. ErythroMer can be freeze-dried or “lyophilized”, for a much longer shelf life than stored blood. It is covered by issued U.S. patents that specify composition of matter, method of preparation, and use as an oxygen carrier.
No matter the industry or plant, every green industry professional wants to nurture the healthiest plant possible while being good stewards to the land. Holganix is the manufacturer of Holganix Bio 800 technology. Holganix Bio 800 harnesses the power of over 800 species of soil microbes to improve crop yield, reduce the need for fertilizer and promote soil health.
Since Bio-Rad was founded 70 years ago, we have continued to provide the healthcare industry with innovative and useful products that help life science researchers accelerate the discovery process and medical diagnostic labs obtain faster, better results. Throughout our existence, we have built long-lasting customer relationships that help advance our research and development efforts in the introduction of new products and solutions. Today, Bio-Rad is a global leader, with a team of over 8,000 employees and a global network of operations that serves our life science research and clinical diagnostics customers, helping people live longer, healthier lives.
Sapient is an end-to-end biomarker discovery partner for pharmaceutical and biotechnology sponsors, providing solutions from large-scale untargeted discovery screening of small molecule biomarkers through development of targeted, quantitative CLIA assays to support drug programs at every phase. Our platform combines next-gen rapid liquid chromatography-mass spectrometry (rLC-MS) technologies – able to assay >11,000 small molecule biomarkers per biosample – computational learning, and an expansive proprietary Human Biology Database with data from several hundred thousand biosamples. Together these approaches enable discovery of circulating biomarkers at unprecedented speed and scale, and rapidly deliver actionable insights that align patients, disease biology, and specific therapies. Sapient's platform reduces the time and complexity of biomarker discovery and validation, and drives greater understanding of biological processes, disease progression, and drug responsiveness to optimize drug pipelines for success and accelerate clinical development.
PHusis Therapeutics is developing novel targeted small molecule therapeutics
Velocity Clinical Research is an Owned Clinical Site Business comprised of 30 fully-integrated, centrally controlled research sites. Our model delivers superior accelerated enrollment and consistent, reliable results – helping our clients maintain the highest standards of care while bringing disruptive, innovative medical treatments to patients as quickly and efficiently as possible. We are driving improvement of the clinical research industry by advancing site-level productivity by further developing efficiencies that can only be achieved in an owned site model, ultimately leading to improved study execution.
