Location: This position may be performed remotely, but requires the flexibility and willingness to travel as needed.
The Opportunity
You will own and shape how Praxis designs, governs, secures, and operates AWS at scale—from account structure and identity to the platforms and applications that run on them. You will be a hands-on builder, using your depth in cloud infrastructure and software engineering to create secure, reliable systems that enable our teams to move quickly.
You will work at the intersection of software engineering, cloud infrastructure, security, and operations. You will build and improve the systems that keep our teams moving fast while maintaining high standards for reliability, security, and compliance. You will work primarily in TypeScript and Python, use modern AI tooling as part of your daily engineering workflow, and take direct accountability for production operations, including on-call.
You will be expected to see problems, take ownership, and drive them through resolution. You will move quickly through incremental, well-controlled changes, question assumptions when there is a better path, and turn operational learnings into durable improvements. Just as importantly, you will raise the bar for the people and systems around you by sharing what you know, communicating clearly, and helping the broader team build and operate better.
Primary Responsibilities
- Own and evolve AWS architecture for enterprise workloads, including multi-account foundations, landing zone / Control Tower patterns, networking, security baselines, and shared platforms.
- Establish and continuously improve AWS governance, including organizational structure, SCPs, tagging, cost controls, compliance, audit readiness, and durable operational standards.
- Design and operate identity and access across AWS, including IAM, IAM Identity Center, and Microsoft Entra ID integrations for SSO, federation, role mapping, access reviews, and least-privilege access.
- Build, harden, and operate AWS platforms and full-stack services using TypeScript and Python, including compute, containers, serverless, data stores, messaging, and cloud automation as needed.
- Drive operational excellence across AWS platforms and workloads by building effective monitoring, alerting, dashboards, SLOs/SLIs, runbooks, incident response practices, and durable fixes to recurring problems; participate in the on-call rotation and own incidents through resolution and learning.
- Automate infrastructure and delivery through Infrastructure as Code—preferably Pulumi and/or SST—and CI/CD using Bitbucket Pipelines and/or GitHub Actions, with an emphasis on safe, incremental delivery and low blast radius.
- Partner across engineering and IT to translate needs into secure, maintainable solutions, improve production readiness and operational practices, mentor other engineers, and use sound judgment to move fast without breaking things.
Qualifications
- Senior-level software engineering experience, with substantial hands-on experience building and operating production systems on AWS.
- Strong full-stack engineering capability in TypeScript and Python, including APIs, services, tooling, and cloud automation.
- Deep experience with core AWS services used in enterprise environments, including IAM, Organizations, VPC, EC2, ECS/EKS or Lambda, S3, RDS/DynamoDB, CloudWatch, KMS, Config, and GuardDuty.
- Proven ability to design and operate AWS governance at scale, including multi-account strategy, policy guardrails, access control, security standards, and operational controls.
- Strong AWS networking fundamentals, including VPNs, peering, Transit Gateway, routing, DNS, and hybrid connectivity.
- Experience with enterprise SSO; Microsoft Entra ID (Azure AD) federation into AWS is strongly preferred, including SAML/OIDC, IAM Identity Center, application and role mapping, and access lifecycle practices.
- Experience working in regulated or audit-ready environments, with strong habits around change control, evidence and traceability, least privilege, and durable controls.
- Demonstrated operational ownership: able to establish meaningful alerts and monitors, reduce noise, improve reliability, respond to incidents, and turn operational learnings into engineering improvements.
- Strong Infrastructure as Code experience; Pulumi and/or SST strongly preferred. Terraform or AWS CDK experience is transferable and welcome.
- Experience with Bitbucket Pipelines and/or GitHub Actions.
- Proficient with modern AI coding and productivity tools, with the judgment to validate outputs, test changes, manage risk, and maintain production quality.
- The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. You'll need comfort with screen work, basic hand coordination, and focus. Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.
Compensation & Benefits
At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive. This includes 99% of the premium paid for medical, dental and vision plans. We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future? We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP. We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns. Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring. We aim high, collaborate hard, and produce results. Let’s achieve the impossible together!
Company Overview
Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.
Diversity, Equity & Inclusion
Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.
Attention: Job Scam Alert
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Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.
Skills Required
- Senior-level software engineering experience with substantial hands-on experience building and operating production systems on AWS
- Strong full-stack engineering capability in TypeScript and Python, including APIs, services, tooling, and cloud automation
- Deep experience with AWS IAM, Organizations, VPC, EC2, ECS or EKS, Lambda, S3, RDS or DynamoDB, CloudWatch, KMS, Config, and GuardDuty
- Experience designing and operating AWS governance at scale, including multi-account strategy, policy guardrails, access control, security standards, and operational controls
- Strong AWS networking fundamentals, including VPNs, peering, Transit Gateway, routing, DNS, and hybrid connectivity
- Experience with enterprise SSO, including SAML or OIDC, IAM Identity Center, application and role mapping, and access lifecycle practices
- Experience working in regulated or audit-ready environments, with change control, evidence and traceability, least privilege, and durable controls
- Demonstrated operational ownership, including monitoring, alerting, reliability improvement, incident response, and operational learning
- Strong Infrastructure as Code experience
- Experience with Bitbucket Pipelines and/or GitHub Actions
- Proficiency with modern AI coding and productivity tools, including validating outputs, testing changes, managing risk, and maintaining production quality
- Microsoft Entra ID federation into AWS, including SAML/OIDC, IAM Identity Center, application and role mapping, and access lifecycle practices
- Pulumi and/or SST experience
- Terraform or AWS CDK experience
- Ability to communicate clearly, use a computer and office equipment regularly, and perform basic movement and hand coordination
What We Do
Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. Praxis is applying insights into the genetic mutations that drive excitation-inhibition imbalance in diseases to select biological targets for rare and more prevalent neurological disorders. We share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Praxis is applying genetic insights to the discovery and development of therapies for rare and more prevalent neurological disorders through our proprietary small molecule platform, Cerebrum™, and antisense oligonucleotide (ASO) platform, Solidus™, using our understanding of shared biological targets and circuits in the brain.
