Description
About BBOT
BBOT is a clinical-stage biopharmaceutical company advancing a next-generation pipeline of novel small molecule therapeutics targeting RAS and PI3K malignancies. BBOT has the goal of improving outcomes for patients with cancers driven by the two most prevalent oncogenes in human tumors. For more information visit BBOTx.com.
Who You Are
This is an exciting opportunity for a highly motivated Pharmacology Operations Research Associate II to contribute to drug discovery activities for the development of novel small molecule cancer therapeutics as part of our cancer biology discovery team. The successful candidate will collaborate with team members to conduct a variety of in vivo oncology models. This position also requires some lab management and operational tasks. We are looking for a talented and enthusiastic individual who thrives in a collaborative, fast-paced and growing environment to join our team.
Responsibilities
- Execute in vivo pharmacology studies including preparation (e.g. ear tagging, shaving), tumor measurements, compound dosing (e.g., po, sc, ip, iv), blood collection and processing, and tissue harvests
- Adhere to institutional SOPs and IACUC protocols to ensure compliant and ethical animal care and handling
- Upload and manage experimental data in vivarium management systems and ELN in a timely and organized manner
- Write study protocols and graph data using Prism
- Prepare formulation buffers and compound dosing solutions for small molecules
- Maintain lab inventory, equipment, and supplies at multiple sites and oversee procurement of supplies
- Oversee health monitoring of holding rooms, which includes sampling of rodent cages and work surfaces and sending out to third party for testing
- Contribute to a collaborative, high-performing team environment, and promote operational improvement initiatives
Requirements
Education and Qualifications
- BS in a biology-related discipline with at least 4 years hands-on experience in a vivarium performing oncology pharmacology studies
- Industry experience highly preferred
- Highly motivated, proactive, and committed individual with good organizational skills
- Ability to work independently in a fast-paced, start-up work environment
- AALAS certification (ALAT, LAT, or LATG) is preferred
- Strong written and oral communication skills
Work Location
This position is based in South San Francisco, CA and operates on a Tuesday - Saturday schedule, with additional rotating coverage for evenings, weekends, and holidays as needed.
Why Join Us?
- Join a fast-paced, mission-driven biotech team focused on delivering transformational therapies
- Competitive salary, benefits, and meaningful equity participation in a public company
Pay Description
This is a contractor position for 40 hours per week with a salary range of $42 - $46 per hour in the San Francisco Bay Area.
Skills Required
- Bachelor of Science degree in a biology-related discipline
- At least 4 years of hands-on vivarium experience performing oncology pharmacology studies
- Industry experience
- AALAS certification such as ALAT, LAT, or LATG
- Strong written and oral communication skills
- Ability to work independently in a fast-paced startup environment
- Strong organizational skills
- Availability for a Tuesday-Saturday schedule with rotating evening, weekend, and holiday coverage
What We Do
BridgeBio Oncology Therapeutics (BBOT) is a clinical-stage biopharmaceutical company developing bioavailable small-molecule inhibitors for cancers driven by RAS and PI3K pathways. Its research explores novel approaches to the RAS signaling pathway and creates RAS-targeted small molecules, including approaches to inhibit KRAS in both active and inactive states and RAS-driven PI3Kα activation. The company aims to deliver well-tolerated medicines with greater efficacy and safety for people with deadly cancers.
