At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.
LP2 MES Technical Lead & Systems Architect — Lebanon, Indiana
Lilly is building a new gene therapy manufacturing site (LP2) in Lebanon, Indiana. This role owns the Manufacturing Execution System (MES) end-to-end — from the Tulip application layer and Tulip Table data model, through MuleSoft integrations connecting SAP, QbDVision, and LabVantage, to the MQTT-based Unified Namespace driving real-time equipment communication. You will serve as both the technical authority over the platform’s architecture and the hands-on engineer responsible for its ongoing design, build, and validation.
Key Responsibilities
Serve as Technical Lead/SME for LP2 MES architecture, design standards, and technical direction
Design, build, and validate Tulip applications for GxP manufacturing workflows and electronic batch records
Direct automation integrations with Automation Engineering (equipment commands, confirmations, process value subscriptions)
Author/approve design specs ensuring compliance with ALCOA+ and 21 CFR Part 11
Guide components through validated migration lifecycle (DEV → QA → Production)
Participate in Change Control Board (CCB) and ServiceNow change management
Partner with Manufacturing Operations, Automation Engineering, and Quality (BQA/CSQA)
Mentor MES engineers; act as escalation point for complex issues
Collaborate with MES Product Owner on ALM requirements/backlog
Report system status and technical risk to site/IT leadership
Basic Requirements
Bachelor's degree in IT, Software/Computer Engineering or related field
5+ years with MES or pharma manufacturing IT platforms, including system integration (middleware/ERP/PLM) and Computer System Validation (CSV) in GMP settings
Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.
Additional Skills/Preferences
Modern software architecture and integration patterns
MuleSoft/Anypoint, DataWeave for MES–ERP(SAP)–PLM integrations
MQTT, Unified Namespace (UNS), OPC UA knowledge
CSV experience: Validation/Test Plans, IQ/OQ/UAT, design specs under 21 CFR Part 11/ALCOA+
Understanding of eBRs, non-terminal record controls, e-signatures
Git/GitHub, GitHub Actions, MUnit, ALM/Jira
Familiarity with MABL and ServiceNow
Strong cross-functional communication and problem-solving skills
Additional Information:
Position Location: Lebanon, Indiana, with potential travel to other U.S. and global Lilly sites as required.
Travel Percentage (%): <10
Shift Information: Role is Monday through Friday and based on-site. Must be flexible in providing support to accommodate production schedules, batch execution windows, and change control activities. Occasional extended hours and/or off-hour support may be required.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is
$129,000 - $211,200Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
#WeAreLilly
Skills Required
- Bachelor’s degree in IT, Software Engineering, Computer Engineering, or a related field
- Five or more years of experience with MES or pharmaceutical manufacturing IT platforms
- Experience with system integration involving middleware, ERP, or PLM platforms
- Computer System Validation experience in GMP settings
- Authorization to work full-time in the United States without sponsorship
- Experience with modern software architecture and integration patterns
- MuleSoft, Anypoint, and DataWeave experience
- MQTT, Unified Namespace, and OPC UA knowledge
- CSV experience with validation/test plans, IQ/OQ/UAT, and compliant design specifications
- Understanding of electronic batch records, non-terminal record controls, and electronic signatures
- Experience with Git, GitHub, GitHub Actions, MUnit, ALM, or Jira
- Familiarity with MABL and ServiceNow
- Strong cross-functional communication and problem-solving skills
Eli Lilly and Company Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Eli Lilly and Company and has not been reviewed or approved by Eli Lilly and Company.
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Retirement Support — Feedback suggests long-term savings are bolstered by a defined-benefit pension alongside a company 401(k) match and retiree health options. These elements make total compensation feel strong beyond base salary.
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Leave & Time Off Breadth — Feedback suggests paid time off is expansive, with substantial vacation, company shutdown days, and milestone time. This breadth of leave is viewed as a meaningful part of overall rewards.
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Parental & Family Support — Feedback suggests family-building and caregiving support are robust, including paid parental leave, adoption or surrogacy assistance, and backup care. These programs enhance the perceived value of benefits across life stages.
Eli Lilly and Company Insights
What We Do
Eli Lilly and Company engages in the discovery, development, manufacture, and sale of products in pharmaceutical products business segment. For more than a century, we have stayed true to a core set of values – excellence, integrity, and respect for people – that guide us in all we do: discovering medicines that meet real needs, improving the understanding and management of disease, and giving back to communities through philanthropy and volunteerism.
