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Job Function:
Discovery & Pre-Clinical/Clinical DevelopmentJob Sub Function:
Biological ResearchJob Category:
Scientific/TechnologyAll Job Posting Locations:
Spring House, Pennsylvania, United States of AmericaJob Description:
About Innovative MedicineOur expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
We are searching for the best talent for a Senior Scientist, Mass Spectrometry to be located in Spring House, PA.
Purpose: The Senior Scientist, Mass Spectrometry (MS) will join the Biophysics team within the Biologics Discovery (BD) organization. In this role, you will serve as a scientific leader and subject matter expert in advanced structural mass spectrometry, driving strategy, innovation, and application of MS based technologies to support discovery and optimization of protein therapeutics, including multispecific antibodies and antibody–drug conjugates (ADCs).
The preferred candidate will have demonstrated scientific expertise in applying advanced mass spectrometry approaches to accelerate characterization of protein therapeutics.
- Providing scientific leadership for protein mass spectrometry capabilities supporting biologics discovery programs.
- Driving structure–function analyses and mechanistic understanding of target binding to inform lead selection, engineering, and optimization decisions.
- Designing, interpreting, and integrating advanced MS experiments (intact MS, peptide mapping, HDX-MS) to support complex discovery and developability questions.
- Championing the development, qualification, and implementation of new analytical technologies, software, and workflows to improve throughput, data quality, and scalability.
- Acting as a technical advisor to project teams, collaborating closely with biophysics, protein engineering, protein expression, computational biology, and other discovery functions.
- Representing the function through internal scientific reviews, governance forums, and external publications or presentations, maintaining a strong scientific presence for the organization.
Education:
- PhD in Analytical Chemistry, Biochemistry, Biophysics, or a related scientific field with 2+ years of relevant experience; or a Master's degree with 5+ years; or a Bachelor's degree with 8+ years of directly applicable experience in mass spectrometry-based protein characterization is required.
Required:
- Experience in LC/MS, LC/MS/MS, intact protein MS, and peptide mapping for biologic characterization is required.
- Expertise in structural mass spectrometry strategies, (i.e., HDX-MS, and/or Footprinting MS, etc.) with a demonstrated ability to apply the technique to complex biologics and discovery stage questions is required.
- Experience in discovery/development of therapeutic antibodies is required.
- Strong proficiency with mass spectrometry data analysis software (e.g., Protein Metrics, HD Examiner, Proteome Discoverer) and high-quality scientific reporting is required.
- Ability to communicate complex data and partner effectively in highly matrixed environments is required.
- Experience with Trajan HDX–Thermo Orbitrap MS platforms is preferred.
- Hands on expertise in chemical cross linking and/or protein footprinting MS approaches is preferred.
- Strong publication and presentation record in structural MS or protein biophysics is preferred.
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.
Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers, internal employees contact AskGS to be directed to your accommodation resource.
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Required Skills:
Preferred Skills:
Accelerating, Analytical Reasoning, Clinical Data Management, Critical Thinking, Data Analysis, Data Reporting, Data Savvy, Design of Experiments (DOE), Drug Discovery Development, Issue Escalation, Molecular Diagnostics, Pharmaceutical Microbiology, Product Knowledge, Research Proposals, Scientific Research, Standard Operating Procedure (SOP), Technologically SavvyJohnson & Johnson Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Johnson & Johnson and has not been reviewed or approved by Johnson & Johnson.
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Healthcare Strength — Healthcare coverage is characterized as comprehensive across medical, dental, and vision, with added supports like onsite clinics, fitness centers, and Employee Assistance resources. Mental-health services and wellbeing reimbursements are also described as meaningful components of the overall package.
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Retirement Support — Retirement offerings are portrayed as a major differentiator, combining a 401(k) with employer matching and an employer-funded pension plan. Stock options and other long-term financial supports are also positioned as part of the broader rewards mix.
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Parental & Family Support — Family-related benefits are presented as notably strong, including paid parental leave for all new parents and additional leave types for caregiving and bereavement. Financial assistance for adoption, fertility treatment, and surrogacy is highlighted as a significant support.
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