Senior Scientist - Lipidomics

At Pfizer, our purpose is to deliver breakthroughs that transform patients' lives. Central to this mission is our Research and Development team, dedicated to translating advanced science and innovative technologies into impactful therapies and vaccines. In this role, you will be at the forefront of this effort, ensuring that our daily activities align with our unwavering commitment to quality. Your work will accelerate the delivery of best-in-class medicines to patients globally, fulfilling Pfizer's commitment to making a meaningful difference in healthcare.
ROLE SUMMARY
The Internal Medicine Research Unit (IMRU) at Pfizer seeks a Lipidomics Senior Scientist to advance research in metabolic diseases, ASCVD and CHIP. This role requires application of advanced mass spectrometry to uncover disease biology, and to identify and validate therapeutic targets. Responsibilities include maintaining lab excellence, communicating findings internally and externally, supporting technological and methodological innovation, and collaborating to interpret multi 'omics data. In addition to drug discovery interests, publication in high-impact journals and presentation of research is encouraged. The candidate will have daily interactions with a team of creative and innovative scientists in a supportive environment for rigorous scientific and drug development training. Strong self-motivation, extensive mass spectrometry experience, excellent communication interpersonal skills, and the ability to work independently and as part of a team are essential.
What You Will Achieve
In this role, you will:

• Design and collaboratively execute in vitro and in vivo lipidomics experiments across ASCVD and metabolic indications to drive decision-making, uncover pathogenic disease biology, and identify new therapeutic targets
• Seek out, propose and implement cutting-edge mass spectrometry technology for qualitative and quantitative analysis of endogenous lipids
• Internalize, optimize and implement new sample preparation procedures in step with advancing industry and academic standards
• Advance the integration ion mobility, gas, and liquid chromatography, keeping the lab at the forefront of advances in separation sciences
• Educate and promote the interrogation of lipid biology in the study of Internal Medicine Research Unit (IMRU) priority diseases including ASCVD, obesity, sarcopenia, and Clonal hematopoiesis of indeterminate potential
• Develop and apply LCMS methods to acquire, analyze and interpret lipiodomics data.
• Collaborate with computational biologists to integrate lipidomics with other 'omics data
• Maintain and troubleshoot LCMS instrumentation
• Actively participate in scientific discussions within and outside Pfizer by attending conferences, presenting work, and publishing in high-impact journals.

Qualifications
Must Have

• Ph.D. in Chemistry, Biochemistry, or a related field with 0 to 4 years of applied mass spectrometry metabolomics/lipidomic, OR MS with 7 to 8 years of applied mass spectrometry metabolomics/lipidomic experience
• Deep understanding of fundamentals of separation science including liquid and gas
• Extensive experience operating modern HRAM platforms and associated data analysis package
• Proficiency in LCMS method development and fit-for-purpose validation
• Demonstrated ability to work collaboratively to achieve results in a fast-paced, dynamic environment
• Excellent written and oral communication skills
• Strong problem-solving skills
• Ability to foster a culture that values scientific excellence, urgency, and partnerships with key stakeholders

Nice to Have

• Experience integrating AI/ML with data processing
• Hands on experience applying Bruker and Thermo MS instrumentation to analyze lipids
• Ion mobility experience
• Stable isotope tracing experience
• Demonstrated mentoring and leadership skills

PHYSICAL/MENTAL REQUIREMENTS

• Lifting, sitting, bending, standing, walking

Other Job Details

• Relocation support available
• Work Location Assignment: On Premise

The annual base salary for this position ranges from $90,900.00 to $151,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Research and Development