Scientist, Protein Therapeutics

For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.
 

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.
 

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.
Job Description
 

Gilead's mission is to discover, develop, and deliver therapies that will improve the lives of patients with life-threatening illnesses worldwide. The Protein Engineering group is a specialized team within the Protein Therapeutics department that is responsible for the optimization and engineering of large molecule drug candidates. We seek a highly motivated Scientist, Protein Therapeutics to contribute to the engineering of novel antibody binding domains, fusion proteins (e.g. cytokines), and multispecific formats. The successful candidate will support cross-functional project teams to develop novel biologics for clinical development.

In this laboratory-based role, the successful candidate will support efforts to optimize large molecule therapeutics. The candidate will implement structure-based design and molecular biology approaches to rapidly generate engineered large molecule therapeutics for diverse target classes.

Additional job requirements:

• Carry out humanization, liability remediation, and other biophysical property improvement and/or affinity tuning of large molecules utilizing rational in silico design approaches.

• Interpret protein structural models to aid in rational protein design.

• Enable fast generation of antibodies and/or multispecifics by utilizing state-of-the-art molecular biology and/or library-based approaches.

• Represent the Protein Therapeutics department on inter-disciplinary project teams and guide preclinical development of large molecule therapeutics.

• Maintain familiarity with scientific literature and independently design, execute, analyze, and interpret experiments.

• Effectively communicate and present project goals and experimental findings to diverse audiences.

• Organize and execute multiple projects in a collaborative team setting.

• Thrive in a fast paced, data-driven and scientifically rigorous environment.

• Maintain compliance with company policies and record keeping.

Basic QualificationsApplicants must have a degree in structural biology, biochemistry, molecular biology or a related field.

Bachelor's Degree and Seven Years Experience

OR

Masters' Degree and Five Years Experience

OR

Ph.D. and Zero to One Year of Relevant Professional Experience

Preferred Qualifications

• Proficiency with structure-based (e.g. PyMOL, MOE, Chimera, AlphaFold, ImmuneBuilder, etc) protein engineering and design is required. Experience using computational design software (e.g. Rosetta, MPNN, etc) is a plus.

• Proficient in antibody engineering, including experience with antibody variable domain reformatting, humanization, sequence liability remediation, and/or biophysical property improvement.

• Proficient in various molecular biology and/or library building techniques (e.g. PCR fragment assembly, vector design, site-directed mutagenesis, Gibson assembly, and/or Golden gate cloning) and protein purification (e.g. SEC, IEX, IMAC, etc).

• Experience with multispecific antibody format design, including design of fusion proteins (e.g. immunocytokines, etc).

• Familiarity with in vitro protein screening methodologies (e.g. cell-based reporter assays, FACS, ELISA, Octet, Carterra, etc).

• Excellent communication and organizational skills.

• Ability to multi-task and self-motivated with excellent problem-solving skills.

People Leader Accountabilities

• Create Inclusion - knowing the business value of diverse teams, modeling inclusion, and embedding the value of diversity in the way they manage their teams.

• Develop Talent - understand the skills, experience, aspirations and potential of their employees and coach them on current performance and future potential. They ensure employees are receiving the feedback and insight needed to grow, develop and realize their purpose.

• Empower Teams - connect the team to the organization by aligning goals, purpose, and organizational objectives, and holding them to account. They provide the support needed to remove barriers and connect their team to the broader ecosystem.

Gilead Core Values

• Integrity (Doing What’s Right)

• Inclusion (Encouraging Diversity)

• Teamwork (Working Together)

• Excellence (Being Your Best)

• Accountability (Taking Personal Responsibility)

The salary range for this position is: $146,540.00 - $189,640.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact [email protected] for assistance.
 

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For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.