Company Overview
Beam Therapeutics is a biotechnology company committed to establishing the leading, fully integrated platform for precision genetic medicines. To achieve this vision, Beam has assembled a platform that includes a suite of gene editing and delivery technologies and is in the process of building internal manufacturing capabilities. Beam’s suite of gene editing technologies is anchored by base editing, a proprietary technology that is designed to enable precise, predictable and efficient single base changes, at targeted genomic sequences, without making double-stranded breaks in the DNA. This has the potential to enable a wide range of potential therapeutic editing strategies that Beam is using to advance a diversified portfolio of base editing programs. Beam is a values-driven organization committed to its people, cutting-edge science, and a vision of providing life-long cures to patients suffering from serious diseases.
Position Overview:
Beam is seeking a highly talented and motivated Principal Research Associate to join our growing mRNA Process Development team. The Principal Research Associate will be responsible for executing late-stage mRNA process development activities, with a focus on downstream purification. The individual will have the opportunity to work with a dynamic and collaborative team across a range of technical areas. They will be tasked with supporting experimental design, execution and data analysis as well as authoring technical documents and reports.
This role is onsite 5 days/week in Cambridge, MA
Responsibilities:
- Support the design and execution of mRNA purification studies to support process development
- Use DoE and other statistical tools to help characterize our processes and to develop control strategies
- Help manufacture materials for use in process development
- Support external and internal tech transfers
- Effectively document, interpret and communicate technical results
- Work cross-functionally to support Beam programs to ensure critical timelines are met
Qualifications:
- Bachelor’s or Master’s Degree in related science with 10 years of relevant experience (e.g. chemical engineering, biochemical engineering, biochemistry etc)
- Experience with mRNA purification technologies is preferred (chromatography and TFF)
- Knowledge of mRNA manufacturing processes
- Highly organized and detail oriented with strong communication skills
- Motivated to learn and to execute process development studies in the lab
- A collaborative mindset
The salary range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, education, scope of job, internal comparisons, and market data.
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What We Do
Beam Therapeutics, launched in 2018, is pioneering the use of CRISPR base editing to develop a broad portfolio of advanced genetic medicines. Our groundbreaking base editing technology allows us to make permanent, specific edits to single bases in DNA and RNA, without cutting the strands. Base editor therapeutics represent a new class of “precision genetic medicines,” combining precision targeting of the genome with precision control of editing outcomes.
Our dream is to provide life-long cures for patients suffering from serious diseases.
The Beam Team Is:
• A community of fearless innovators
• Rigorous and honest in our research
• Listening with open minds
• Committed to each other
