GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on alleviating the global burden of cancer by developing pioneering technology to detect and identify multiple deadly cancer types early. The company is using the power of next-generation sequencing, population-scale clinical studies, and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology, and to develop its multi-cancer early detection blood test. GRAIL is headquartered in Menlo Park, CA with locations in Washington, D.C., North Carolina, and the United Kingdom. GRAIL, LLC is a wholly-owned subsidiary of Illumina, Inc. (NASDAQ:ILMN). For more information, please visit www.grail.com.

GRAIL is seeking a Supervisor for the Core Lab reporting to the Technical Operations team in Menlo Park. The ideal candidate is a demonstrated team leader with hands-on laboratory experience. The candidate will be encouraged to creatively solve operational and logistical problems while executing NGS workflows in collaboration with many functions of our organization. The Supervisor will manage a complex schedule of activities and own management and execution of experiments under the direction of management, scientists, and engineers. The candidate will be instrumental in supporting experimental, development, and pharma partnership assays, developing SOPs and supporting documentation, and carrying out day-to-day operations within GRAIL laboratories.

You will:

• Manage a complex and dynamic schedule of experiments for development partnerships, internal and external research, and evolution of Grail’s commercial products
• Coordinate implementation of new workflows, incorporating input from various stakeholders including R&D, Biosample Operations, and Supply Chain
• Execute automated and manual sample preparation and NGS assays
• Accurately plan and document laboratory work performed per GLP
• Support troubleshooting and root cause analysis for issues with core lab automated and manual sample processing and NGS workflows
• Document investigations and reports per regulatory and study requirements (SOW/CAP/CLIA/FDA)
• Develop expertise in workflows used in current production and research assays
• Ensure laboratory activities are performed in compliance with procedures and safety guidelines when handling, storing, and disposing of hazardous or bio-hazardous materials

Your qualifications and background will include:

• Minimum of B.Sc. in Biology, Chemistry, or a related field with 5+ years of related experience. Job Title/Level will be based on education and experience
• Effective written and verbal communication skills (proficiency in English) as well as strong interpersonal, negotiation, and influencing skills
• Experienced team leader with demonstrated ability to prioritize in a high pace environment
• Strong planning, prioritization, problem-solving, and organizational skills
• 2+ years of experience in Next Generation Sequencing assays and workflows preferred
• Experience with Automated sample preparation workflows is a plus
• Familiarity with molecular biology techniques (e.g. pipetting, SPRI, PCR, qPCR)
• Familiarity with nucleic acids extraction techniques and quantification devices (e.g., Nanodrop, Bioanalyzer, Fragment Analyzer, ddPCR) is a plus
• Practical knowledge of Next Generation Sequencing sample preparation workflows and applications preferred.
• General digital literacy and proficiency in GSuite
• Data analysis using tools such as JMP, or proficiency with R or Python is a plus

GRAIL is an Equal Employment Office and Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status. We will reasonably accommodate all individuals with disabilities so that they can participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Following extensive monitoring, research, consideration of business implications, and advice from internal and external experts, GRAIL has made the decision to require all U.S. employees receive the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.