GRAIL
GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured.
Raleigh-Durham, NC

Staff / Lead Process Engineer (Tech Ops) - RTP #2165 (Raleigh, NC)

| Raleigh-Durham, NC
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GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on alleviating the global burden of cancer by developing pioneering technology to detect and identify multiple deadly cancer types early. The company is using the power of next-generation sequencing, population-scale clinical studies, and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology, and to develop its multi-cancer early detection blood test. GRAIL is headquartered in Menlo Park, CA with locations in Washington, D.C., North Carolina, and the United Kingdom. GRAIL, LLC is a wholly-owned subsidiary of Illumina, Inc. (NASDAQ:ILMN). For more information, please visit www.grail.com.

GRAIL is seeking a Process Engineer in Technical Operations in our North Carolina (RTP) facility.
The ideal candidate is a team player with hands-on experience developing, implementing, qualifying,
executing, and troubleshooting automated molecular testing procedures and a willingness to lead
and teach others. The candidate will be encouraged to think outside of the box and creatively solve
problems related to the optimization, verification, and execution of NGS-based workflows. They will
work collaboratively across many organizational functions, using a data-driven approach to identify
areas for improvement. The successful candidate will demonstrate an ability to independently design
and execute experiments, develop compliant (GMP/GCLP/ISO/CAP/CLIA) qualification plans, and
serve as SME to support validation activities. The candidate will be instrumental in documenting and
resolving non-conformances, and performing in-depth investigations to support the implementation of
process improvements in support of GRAIL operations.

YOU WILL:

  • Use deep knowledge of automated liquid handling systems, NGS workflows, general
  • biochemistry and molecular biology, and scientific best practices to develop novel solutions
  • to assess verification/validation readiness, identify and address gaps, improve assay
  • robustness
  • Independently design, execute, and analyze data from experiments to support the
  • optimization, characterization, and validation of novel automated NGS-based assays
  • Supervise cross-functional testing and documentation from initiation to completion of assay
  • version updates
  • Work closely with Technical Operations Verification and Validation team members to identify
  • and document methods, parameters, acceptance criteria appropriate for V&V testing
  • Employ data-driven approach to identify, design, characterize, and effectiveness-check
  • improvements
  • Identify internal SMEs and lead cross-functional teams to identify appropriate parameters
  • and metrics for process monitoring
  • Summarize proposed method changes/improvement accurately and succinctly, and
  • document appropriately within a GMP/ISO regulatory-compliant Quality Management System
  • Support design and maintenance of databases to inform data-driven process improvements
  • Serve as Technical Operations SME for equipment, equipment performance specifications,
  • and processes related to execution of current GRAIL automated NGS assays
  • Use Lean/6-Sigma methods to research and characterize areas of improvement
  • Use productivity software to track and report progress
  • Support nonconformance containment activities, as needed
  • Mentor junior scientific and engineering Technical Operations staff

YOUR BACKGROUND AND QUALIFICATIONS WILL INCLUDE:

  • Minimum of B.Sc./M.S. in BioEngineering, Molecular Biology, Biochemistry, or a related field
  • with 8+ years of related experience. Job Title/Level will be based on education and
  • demonstrated experience
  • Demonstrated record of designing, implementing, and troubleshooting automated liquid
  • handling workflows
  • Familiarity with NGS workflows and supporting QC methods (FA, CE, qPCR)
  • Demonstrated technical leadership of cross-functional teams
  • Willingness and ability to learn new techniques independently and quickly
  • Excellent written, organizational, and verbal communication skills (fluency in English)
  • Strong interpersonal, negotiation, and influencing skills
  • General digital literacy and proficiency in G-Suite and/or Microsoft Office Suite required
  • General proficiency in basic multivariate statistical analyses, use of statistical software (JMP,
  • Tableau, SPS, Minitab) required
  • Lean Six Sigma certified: minimum yellow belt required, green/black strongly preferred
  • Proficiency with R, Python, and/or SQL strongly preferred
  • Automated NGS library preparation strongly preferred
  • General knowledge of software development processes preferred

GRAIL is an Equal Employment Office and Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status. We will reasonably accommodate all individuals with disabilities so that they can participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation.
Following extensive monitoring, research, consideration of business implications, and advice from internal and external experts, GRAIL has made the decision to require all U.S. employees receive the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.

GRAIL is an Equal Employment Office and Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status. We will reasonably accommodate all individuals with disabilities so that they can participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Following extensive monitoring, consideration of business implications, and advice from internal and external experts, GRAIL US has made the decision to require that all U.S. employees be “Fully Vaccinated” with the COVID-19 vaccine and “Up to Date” with any recommended booster. “Fully Vaccinated” is defined as two weeks after both doses of a two-dose vaccine (e.g. Pfizer or Moderna) or two weeks since a single-dose vaccine (e.g. Johnson & Johnson) has been administered; "Up to Date" means having timely received any COVID-19 vaccine booster(s) in accordance with CDC guidelines. Absent a qualifying exemption, all GRAIL US employees are to comply with this requirement, including providing documentation of such vaccination status, as a condition of employment. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation for consideration by GRAIL.

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What are GRAIL Perks + Benefits

GRAIL Benefits Overview

We’re committed to creating the best experience for everyone at GRAIL, ensuring that each member of our team has comprehensive benefits and resources to thrive at all stages of life, both at work and at home.

Culture
Friends outside of work
Eat lunch together
Intracompany committees
Daily sync
Open door policy
Team owned deliverables
Team based strategic planning
Group brainstorming sessions
Open office floor plan
Diversity
Dedicated Diversity/Inclusion Staff
Unconscious bias training
Diversity manifesto
Mean gender pay gap below 10%
Diversity Employee Resource Groups
Hiring Practices that Promote Diversity
Health Insurance & Wellness Benefits
Flexible Spending Account (FSA)
Disability Insurance
Dental Benefits
Vision Benefits
Health Insurance Benefits
Life Insurance
Wellness Programs
Onsite Gym
Team workouts
Retirement & Stock Options Benefits
401(K)
Company Equity
Performance Bonus
Child Care & Parental Leave Benefits
Child Care Benefits
Generous Parental Leave
Flexible Work Schedule
Remote Work Program
Family Medical Leave
Company sponsored family events
Vacation & Time Off Benefits
Unlimited Vacation Policy
Paid Holidays
Paid Sick Days
Perks & Discounts
Casual Dress
Commuter Benefits
Free Daily Meals
Game Room
Happy Hours
Parking
Professional Development Benefits
Job Training & Conferences
Diversity Program
Cross functional training encouraged
Promote from within
Mentorship program
Online course subscriptions available

An Insider's view of GRAIL

How does your team reward individual success?

People grow their skills both by learning how to rapidly build scalable software systems, but also by partnering with scientists and other domain experts to better understand, model, and envision the systems we will need. We enable and empower our engineers to lead this process and grow with our systems as they make the future of GRAIL a reality.

Tristan Matthews

Senior Director, Software Engineering

What projects are you most excited about?

GRAIL has a unique opportunity to scale our operations to add value with our early detection test. Our automation team works on the full spectrum of projects from low-level instrument investigations to overall architectures of processing facilities. I'm excited by projects that push the boundaries of lab automation, and that's what GRAIL is doing.

David Jenions

Principal Automation Engineer

What does career growth look like on your team?

Our mission, to detect cancer early, is truly seeking a needle in many haystacks. Our lab has a very complex and sophisticated assay to execute. We leverage cross-training and mentorship programs where new teammates learn the ropes from senior staff. My team sets people up for success by turning tasks into learning opportunities.

Maryam Hosseini

Director, Laboratory Operations

How do your team's ideas influence the company's direction?

The biological problem we're trying to solve is a complex machine learning problem with human lives at stake. From a software engineering point of view, taking massive data, organizing it, building tools to mine it, and deliver results in a scalable, secure, and clinically compliant manner are areas of innovation. This, for me, is my dream job!

Satnam Alag

SVP, Software Engineering

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