Protein Engineer at Battelle (Columbus, OH)

| Columbus, OH
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Battelle delivers when others can't. We conduct research and development, manage national laboratories, design and manufacture products and deliver critical services for our clients-whether they are a multi-national corporation, a small start-up or a government agency.

We recognize and appreciate the value and contributions of individuals with diverse backgrounds and experiences and welcome all qualified individuals to apply.

Battelle is currently seeking a Protein Engineer for the National Security Business Unit. This full-time position is located in Columbus, Ohio. Some domestic and international travel is anticipated.


Technical leadership and support to laboratory studies in the engineering of proteins and enzymes to produce industrially relevant molecules and improved tolerance to toxic compounds, engineering of enzymes involved in pathways for the buildup of high value compounds, and the identification and exploitation of opportunities to lead projects that enhance capability and/or support the development of new technical approaches.


  • Support research projects focused on but not limited to engineering of enzymes to produce industrially relevant molecules at high titers and improve tolerance to toxic compounds.
  • Design protein engineering libraries via rational protein design, directed evolution, synthetic metagenomics, and other approaches.
  • Develop and implement high-throughput screening assays for various proteins and enzymes.
  • Engineer proteins and enzymes to improve catalytic activity, binding affinity, selectivity, solubility, expression, and stability in various host organisms.
  • Express, purify, and characterize protein and enzyme variants of interest.
  • Optimize and develop systems for improved breakdown of valuable feedstocks.
  • Actively engage in interdisciplinary research and collaboration between metabolic engineers, microbiologists, synthetic biologists, and bioinformaticians.
  • Prepare and present technical reports and presentations.
  • Conduct technical work and produce quality results within budget and schedule.
  • Assist in preparing scientific journal publications and presenting at professional meetings.
  • Assist in the development of proposals, marketing plans and identifying business opportunities.
  • Train, mentor, and lead junior technical staff.

Some domestic and potential international travel is anticipated.


  • A Ph.D. (or MS and 5 years' experience or BS and 10 years' experience) in biochemistry or related field with experience in molecular biology, protein engineering and synthetic biology.
  • Experience leading research projects.
  • Ability to travel.
  • U.S. citizenship, with the ability to obtain and maintain required government security clearances as a condition of employment.
  • Sufficiently medically fit to work in the laboratory and in the field to perform assigned duties.
  • The ability to work in a team environment.
  • Excellent written and oral communication skills


  • Experience working within laboratory quality management systems (e.g., ISO 9001, ISO17025, GLP).
  • Experience working with computational approaches to protein engineering.
  • Experience with microfluidics.


The above statements are intended to describe the nature and level of work being performed by people assigned to this job. They are not intended to be an exhaustive list of all responsibilities, activities and skills required of staff members. No statement herein is intended to imply any authorities to commit Battelle unless special written permission is granted by Battelle's Legal Department

Battelle Benefits
Battelle's benefits program supports employees so they can be at their best at home and at work. It's a comprehensive package including:
  • A benefits concierge service to help you understand and use your benefits
  • Paid parental leave and family formation support
  • A holistic wellness community and employee assistance program offering physical, mental, financial, legal and family support

COVID-19 Vaccine

In compliance with President Biden's Executive Order 14042 and the Safer Federal Workforce Task Force COVID-19 Workplace Safety: Guidance for Federal Contractors and Subcontractors, Battelle requires all employees to be fully vaccinated against COVID-19 as a condition of employment and continued employment and to provide documentation that they are fully vaccinated. Battelle will provide reasonable accommodations based on a qualified disability or medical condition through the Americans with Disabilities Act or the Rehabilitation Act or for a sincerely held religious belief under Title VII of the Civil Rights Act of 1964 (and related state laws).

Battelle is an affirmative action and equal opportunity employer. If a reasonable accommodation is needed to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please contact [email protected] .

Battelle is an equal opportunity employer. We provide employment and opportunities for advancement, compensation, training, and growth according to individual merit, without regard to race, color, religion, sex (including pregnancy), national origin, sexual orientation, gender identity or expression, marital status, age, genetic information, disability, veteran-status veteran or military status, or any other characteristic protected under applicable Federal, state, or local law. Our goal is for each staff member to have the opportunity to grow to the limits of their abilities and to achieve personal and organizational objectives. We will support positive programs for equal treatment of all staff and full utilization of all qualified employees at all levels within Battelle.

For more information about our other openings, please visit
More Information on Battelle
Battelle operates in the Energy industry. The company is located in Columbus, OH. Battelle was founded in 1929. It has 5775 total employees. It offers perks and benefits such as Flexible Spending Account (FSA), Disability Insurance, Dental Benefits, Vision Benefits, Health Insurance Benefits and Life Insurance. To see all 39 open jobs at Battelle, click here.
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